Overview
Endogenous fatty acid amide for pain and inflammation.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Activates PPAR-α and indirect CB receptors.
- · Activates PPAR-α
- · indirect CB receptors
Effects on the body
Organ system effects
PEA (Palmitoylethanolamide) modulates innate and adaptive immune responses, including cytokine signaling and barrier function.
Evidence-based benefits
Reduces neuropathic pain
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Autoimmune disease (theoretical immune activation)
- ·Immunosuppressants
Supplement interactions
- Vitamin D3 + K2Foundational immune modulation.
- ZincRequired cofactor for innate and adaptive immune function.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified PEA (Palmitoylethanolamide) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.PEA (Palmitoylethanolamide) third party tested NSF
CapsulesPre-measured PEA (Palmitoylethanolamide) capsules — easiest for travel and consistent daily dosing without scoops or scales.PEA (Palmitoylethanolamide) capsules
PowderBulk unflavored PEA (Palmitoylethanolamide) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.PEA (Palmitoylethanolamide) powder unflavored
Best sellersMost-purchased PEA (Palmitoylethanolamide) products on Amazon — a quick way to see what's reviewed widely before you commit.PEA (Palmitoylethanolamide) best sellerScientific evidence8Show studiesHide studies
PEA in chronic pain
Gabrielsson L, et al.
12 trials
Significant pain reduction across conditions.
PubMed: PEA (Palmitoylethanolamide) — Reduces neuropathic pain
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Google Scholar: PEA (Palmitoylethanolamide) — clinical evidence
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