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Supplements/Compound

Quercetin + Dasatinib (D+Q)

Reference senolytic combination cycled to clear senescent cells.

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Overview

Reference senolytic combination cycled to clear senescent cells.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Forms & variants of Quercetin

Different chemical forms of Quercetin behave differently. Browse each form's mechanism, bioavailability, and best-use context.

Mechanism of action

Inhibits anti-apoptotic Bcl-XL and SRC family kinases in senescent cells.

Pathways
  • · Inhibits anti-apoptotic Bcl-XL
  • · SRC family kinases in senescent cells

Effects on the body

Supports
physical function in IPF (open-label)

Organ system effects

Brain & CNS

Quercetin + Dasatinib (D+Q) acts on hallmarks of aging including oxidative stress, mitochondrial dysfunction, and senescence signaling.

Evidence-based benefits

Improves physical function in IPF (open-label)

Limited evidence

Potential side effects

Common
  • · GI upset
Rare
    Serious
    • · Use only with medical oversight

    Drug interactions

    QT-prolonging drugs
    Dasatinib lengthens QT interval.
    severe

    Supplement interactions

    Pairs well with
    • NAD+ precursor (NMN or NR)
      Complementary mitochondrial and sirtuin support.
    • Omega-3
      Lowers inflammation and supports membrane integrity.
    Avoid combining with

    No specific avoidances listed.

    Dosing & bioavailability

    Typical dose
    Research protocols only
    Best form
    Most evidence is based on the capsule or softgel form.
    Timing
    Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
    With food?
    With a meal containing fat for fat-soluble compounds; otherwise either.

    Where to buy

    Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

    Scientific evidence8Show studies
    CohortEBioMedicine · 2019

    Dasatinib + quercetin in IPF

    Justice JN, et al.

    Open-label trial in 14 IPF patients.

    Key findings

    Improved 6-min walk distance and gait speed.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Quercetin + Dasatinib (D+Q) — Improves physical function in IPF

    Live PubMed search

    Live results for "Quercetin + Dasatinib (D+Q) Improves physical function in IPF" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Quercetin + Dasatinib (D+Q) and "Improves physical function in IPF". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Quercetin + Dasatinib (D+Q) — randomized controlled trial

    Live PubMed search

    Live results for "Quercetin + Dasatinib (D+Q) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Quercetin + Dasatinib (D+Q) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Quercetin + Dasatinib (D+Q) — meta-analysis

    Live PubMed search

    Live results for "Quercetin + Dasatinib (D+Q) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Quercetin + Dasatinib (D+Q) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Quercetin + Dasatinib (D+Q) — pharmacokinetics

    Live PubMed search

    Live results for "Quercetin + Dasatinib (D+Q) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Quercetin + Dasatinib (D+Q) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Quercetin + Dasatinib (D+Q) — safety adverse events

    Live PubMed search

    Live results for "Quercetin + Dasatinib (D+Q) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Quercetin + Dasatinib (D+Q) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Quercetin + Dasatinib (D+Q) — dose response

    Live PubMed search

    Live results for "Quercetin + Dasatinib (D+Q) dose response" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Quercetin + Dasatinib (D+Q) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewGoogle Scholar · 1970

    Google Scholar: Quercetin + Dasatinib (D+Q) — clinical evidence

    Live Scholar search

    Cross-database citation index for Quercetin + Dasatinib (D+Q) as it relates to "clinical evidence".

    Key findings

    Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

    Open study
    Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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