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evidence · mechanism · dose
Supplements/Compound

Quercetin

Flavonoid with antihistamine and senolytic effects; pairs with bromelain or vitamin C.

Immune FunctionHealthy AgingChronic Inflammation

Overview

Flavonoid with antihistamine and senolytic effects; pairs with bromelain or vitamin C.

Natural sources
  • Onions
  • Apples
  • Capers
Common forms
  • Quercetin dihydrate
  • Quercetin phytosome

Forms & variants of Quercetin

Different chemical forms of Quercetin behave differently. Browse each form's mechanism, bioavailability, and best-use context.

D+Q senolytic
Quercetin + Dasatinib (D+Q)

Reference senolytic combination cycled to clear senescent cells.

Mechanism of action

Inhibits mast cell degranulation; senolytic with dasatinib in animals.

Pathways
  • · Mast cell stabilization
  • · Senolysis

Effects on the body

Decreases
Histamine release
Decreases
Inflammatory markers

Organ system effects

Evidence-based benefits

Reduces allergic rhinitis symptoms

Limited evidence

Reduces URI incidence in athletes

Moderate evidence

Potential side effects

Common
  • · Headache
  • · Nausea
Rare
    Serious

      Drug interactions

      CYP3A4 substrates
      Inhibition.
      moderate
      Quinolones
      Reduced efficacy.
      moderate

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid with these conditions
      • ·Autoimmune disease (theoretical immune activation)
      Avoid / monitor with these medications
      • ·Immunosuppressants

      Supplement interactions

      Pairs well with
      • Bromelain
        Boosts quercetin absorption.
      • Zinc
        Quercetin acts as zinc ionophore.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      500–1000 mg/d

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Compound
      Quercetin
      Amazon
      Wide selection · fast shipping
      Compound
      Quercetin
      iHerb
      Global delivery · curated brands
      Compound
      Quercetin
      Thorne
      Practitioner-grade · NSF tested

      Scientific evidence (9)

      Meta-analysisJ Am Heart Assoc · 2016

      Quercetin and blood pressure: a meta-analysis

      Serban MC, et al.

      Meta-analysis of quercetin RCTs.

      Key findings

      Significant reductions in systolic and diastolic BP.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Quercetin — Reduces allergic rhinitis symptoms

      Live PubMed search

      Live results for "Quercetin Reduces allergic rhinitis symptoms" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Quercetin and "Reduces allergic rhinitis symptoms". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Quercetin — Reduces URI incidence in athletes

      Live PubMed search

      Live results for "Quercetin Reduces URI incidence in athletes" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Quercetin and "Reduces URI incidence in athletes". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Quercetin — randomized controlled trial

      Live PubMed search

      Live results for "Quercetin randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Quercetin and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Quercetin — meta-analysis

      Live PubMed search

      Live results for "Quercetin meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Quercetin and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Quercetin — pharmacokinetics

      Live PubMed search

      Live results for "Quercetin pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Quercetin and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Quercetin — safety adverse events

      Live PubMed search

      Live results for "Quercetin safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Quercetin and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Quercetin — dose response

      Live PubMed search

      Live results for "Quercetin dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Quercetin and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Quercetin — clinical evidence

      Live Scholar search

      Cross-database citation index for Quercetin as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.