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Echinacea Purpurea

Coneflower for upper respiratory infections.

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Overview

Coneflower for upper respiratory infections.

Natural sources
  • Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
  • Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
  • Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
Common forms
  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Mechanism of action

Alkylamides activate CB2 receptors; immunomodulatory.

Pathways
  • · Alkylamides activate CB2 receptors
  • · immunomodulatory

Effects on the body

Decreases
URTI severity

Organ system effects

Immune System

Echinacea Purpurea modulates innate and adaptive immune responses, including cytokine signaling and barrier function.

Evidence-based benefits

Reduces URTI severity

Moderate evidence

Potential side effects

Common
  • · GI upset
  • · Rash
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Echinacea Purpurea use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Avoid with these conditions
      • ·Autoimmune disease (theoretical immune activation)
      Avoid / monitor with these medications
      • ·Immunosuppressants

      Supplement interactions

      Pairs well with
      • Vitamin D3 + K2
        Foundational immune modulation.
      • Zinc
        Required cofactor for innate and adaptive immune function.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      300 mg TID
      Best form
      Most evidence is based on the standardized extract capsule form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either with or without food.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      Meta-analysisLancet Infect Dis · 2007

      Echinacea meta-analysis

      Shah SA, et al.

      14 trials

      Key findings

      Reduced URTI incidence 58%.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Echinacea Purpurea — Reduces URTI severity

      Live PubMed search

      Live results for "Echinacea Purpurea Reduces URTI severity" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Echinacea Purpurea and "Reduces URTI severity". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Echinacea Purpurea — randomized controlled trial

      Live PubMed search

      Live results for "Echinacea Purpurea randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Echinacea Purpurea and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Echinacea Purpurea — meta-analysis

      Live PubMed search

      Live results for "Echinacea Purpurea meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Echinacea Purpurea and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Echinacea Purpurea — pharmacokinetics

      Live PubMed search

      Live results for "Echinacea Purpurea pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Echinacea Purpurea and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Echinacea Purpurea — safety adverse events

      Live PubMed search

      Live results for "Echinacea Purpurea safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Echinacea Purpurea and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Echinacea Purpurea — dose response

      Live PubMed search

      Live results for "Echinacea Purpurea dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Echinacea Purpurea and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Echinacea Purpurea — clinical evidence

      Live Scholar search

      Cross-database citation index for Echinacea Purpurea as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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