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evidence · mechanism · dose
Supplements/Compound

Choline Bitartrate

Affordable choline source — supports phospholipid synthesis and methylation.

Brain & CognitiveLiver HealthGeneral Wellness

Overview

Affordable choline source — supports phospholipid synthesis and methylation.

Natural sources
    Common forms

      Mechanism of action

      Choline → phosphatidylcholine and acetylcholine; required for VLDL export from liver.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Prevents NAFLD in deficiency

        Strong evidence

        Potential side effects

        Common
        • · Fishy odor at high dose
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            550 mg AI (men), 425 mg (women)
            With food?
            Optional

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Choline Bita…
            Amazon
            Wide selection · fast shipping
            Compound
            Choline Bita…
            iHerb
            Global delivery · curated brands
            Compound
            Choline Bita…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            CohortAm J Clin Nutr · 2011

            Choline supplementation and cognitive function

            Poly C, et al.

            Framingham Offspring cohort analysis.

            Key findings

            Higher choline intake associated with better verbal memory.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Choline Bitartrate — Prevents NAFLD in deficiency

            Live PubMed search

            Live results for "Choline Bitartrate Prevents NAFLD in deficiency" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Choline Bitartrate and "Prevents NAFLD in deficiency". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Choline Bitartrate — randomized controlled trial

            Live PubMed search

            Live results for "Choline Bitartrate randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Choline Bitartrate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Choline Bitartrate — meta-analysis

            Live PubMed search

            Live results for "Choline Bitartrate meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Choline Bitartrate and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Choline Bitartrate — pharmacokinetics

            Live PubMed search

            Live results for "Choline Bitartrate pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Choline Bitartrate and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Choline Bitartrate — safety adverse events

            Live PubMed search

            Live results for "Choline Bitartrate safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Choline Bitartrate and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Choline Bitartrate — dose response

            Live PubMed search

            Live results for "Choline Bitartrate dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Choline Bitartrate and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Choline Bitartrate — clinical evidence

            Live Scholar search

            Cross-database citation index for Choline Bitartrate as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.