SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Herb

Schisandra (Adaptogen)

Berry adaptogen for stress, focus, and liver protection.

Liver HealthBrain & Cognitive

Overview

Berry adaptogen for stress, focus, and liver protection.

Natural sources
    Common forms

      Forms & variants of Schisandra

      Different chemical forms of Schisandra behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Schisandra

      Adaptogenic berry traditionally used for stamina, liver protection, and stress resilience.

      Mechanism of action

      Lignans modulate HPA axis, Nrf2, and CYP enzymes.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves attention under fatigue

        Moderate evidence

        Potential side effects

        Common
        • · Heartburn
        Rare
          Serious

            Drug interactions

            CYP3A4 substrates
            Induces CYP3A4.
            moderate

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            500–2000 mg
            With food?
            With food

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Schisandra (…
            Amazon
            Wide selection · fast shipping
            Herb
            Schisandra (…
            iHerb
            Global delivery · curated brands
            Herb
            Schisandra (…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTPhytomedicine · 2008

            Schisandra in fatigued workers

            Panossian A, et al.

            5-day trial in 40 stressed adults.

            Key findings

            Improved attention and accuracy under fatigue.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Schisandra (Adaptogen) — Improves attention under fatigue

            Live PubMed search

            Live results for "Schisandra (Adaptogen) Improves attention under fatigue" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Schisandra (Adaptogen) and "Improves attention under fatigue". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Schisandra (Adaptogen) — randomized controlled trial

            Live PubMed search

            Live results for "Schisandra (Adaptogen) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Schisandra (Adaptogen) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Schisandra (Adaptogen) — meta-analysis

            Live PubMed search

            Live results for "Schisandra (Adaptogen) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Schisandra (Adaptogen) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Schisandra (Adaptogen) — pharmacokinetics

            Live PubMed search

            Live results for "Schisandra (Adaptogen) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Schisandra (Adaptogen) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Schisandra (Adaptogen) — safety adverse events

            Live PubMed search

            Live results for "Schisandra (Adaptogen) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Schisandra (Adaptogen) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Schisandra (Adaptogen) — dose response

            Live PubMed search

            Live results for "Schisandra (Adaptogen) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Schisandra (Adaptogen) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Schisandra (Adaptogen) — clinical evidence

            Live Scholar search

            Cross-database citation index for Schisandra (Adaptogen) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.