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Picrorhiza Kurroa

Indian herb for liver protection.

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Overview

Indian herb for liver protection.

Natural sources
  • Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
  • Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
  • Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
Common forms
  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Mechanism of action

Kutkin antagonizes hepatotoxin damage.

Pathways
  • · Kutkin antagonizes hepatotoxin damage

Effects on the body

Supports
Hepatoprotective

Organ system effects

Liver

Picrorhiza Kurroa supports hepatocyte antioxidant defenses (glutathione, Nrf2) and phase-I/II detoxification.

Evidence-based benefits

Hepatoprotective

Moderate evidence

Potential side effects

Common
  • · GI upset
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Picrorhiza Kurroa use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)

      Supplement interactions

      Pairs well with
      • Milk thistle (silymarin)
        Complementary hepatoprotective antioxidant pathways.
      • NAC
        Restores hepatic glutathione.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      400–1500 mg
      Best form
      Most evidence is based on the standardized extract capsule form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either with or without food.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTIndian J Gastroenterol · 1996

      Picrorhiza in viral hepatitis

      Vaidya AB, et al.

      15 patients

      Key findings

      Reduced bilirubin clearance time.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Picrorhiza Kurroa — Hepatoprotective

      Live PubMed search

      Live results for "Picrorhiza Kurroa Hepatoprotective" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Picrorhiza Kurroa and "Hepatoprotective". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Picrorhiza Kurroa — randomized controlled trial

      Live PubMed search

      Live results for "Picrorhiza Kurroa randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Picrorhiza Kurroa and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Picrorhiza Kurroa — meta-analysis

      Live PubMed search

      Live results for "Picrorhiza Kurroa meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Picrorhiza Kurroa and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Picrorhiza Kurroa — pharmacokinetics

      Live PubMed search

      Live results for "Picrorhiza Kurroa pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Picrorhiza Kurroa and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Picrorhiza Kurroa — safety adverse events

      Live PubMed search

      Live results for "Picrorhiza Kurroa safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Picrorhiza Kurroa and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Picrorhiza Kurroa — dose response

      Live PubMed search

      Live results for "Picrorhiza Kurroa dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Picrorhiza Kurroa and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Picrorhiza Kurroa — clinical evidence

      Live Scholar search

      Cross-database citation index for Picrorhiza Kurroa as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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