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evidence · mechanism · dose
Supplements/Amino Acid

L-Glutamine (Gut Barrier)

Preferred fuel for enterocytes — supports intestinal barrier integrity.

Gut HealthIBS SupportAthletic Recovery

Overview

Preferred fuel for enterocytes — supports intestinal barrier integrity.

Natural sources
    Common forms

      Mechanism of action

      Primary fuel for small intestine epithelium; supports tight-junction proteins.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves IBS-D symptoms post-infection

        Moderate evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              5 g BID-TID
              With food?
              Empty stomach

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Amino Acid
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              iHerb
              Global delivery · curated brands
              Amino Acid
              L-Glutamine …
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTGut · 2019

              Oral glutamine in postinfectious IBS with diarrhea

              Zhou Q, et al.

              8-week RCT of 5 g TID glutamine in post-infectious IBS-D.

              Key findings

              Significant reduction in IBS-SSS vs placebo.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: L-Glutamine (Gut Barrier) — Improves IBS-D symptoms post-infection

              Live PubMed search

              Live results for "L-Glutamine (Gut Barrier) Improves IBS-D symptoms post-infection" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching L-Glutamine (Gut Barrier) and "Improves IBS-D symptoms post-infection". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: L-Glutamine (Gut Barrier) — randomized controlled trial

              Live PubMed search

              Live results for "L-Glutamine (Gut Barrier) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching L-Glutamine (Gut Barrier) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: L-Glutamine (Gut Barrier) — meta-analysis

              Live PubMed search

              Live results for "L-Glutamine (Gut Barrier) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching L-Glutamine (Gut Barrier) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: L-Glutamine (Gut Barrier) — pharmacokinetics

              Live PubMed search

              Live results for "L-Glutamine (Gut Barrier) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching L-Glutamine (Gut Barrier) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: L-Glutamine (Gut Barrier) — safety adverse events

              Live PubMed search

              Live results for "L-Glutamine (Gut Barrier) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching L-Glutamine (Gut Barrier) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: L-Glutamine (Gut Barrier) — dose response

              Live PubMed search

              Live results for "L-Glutamine (Gut Barrier) dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching L-Glutamine (Gut Barrier) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: L-Glutamine (Gut Barrier) — clinical evidence

              Live Scholar search

              Cross-database citation index for L-Glutamine (Gut Barrier) as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.