Overview
Stomach acid supplement used for hypochlorhydria; controversial.
- Synthesized
- Betaine HCl + pepsin
Mechanism of action
Provides exogenous HCl in capsule form to lower gastric pH.
- · Gastric acidification
Effects on the body
Organ system effects
May help iron/B12 absorption in hypochlorhydria.
Evidence-based benefits
Improves drug absorption in PPI-induced hypochlorhydria (small studies)
Limited evidencePotential side effects
- · Heartburn
- · Gastritis or ulcer worsening
Drug interactions
Supplement interactions
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
- Active peptic ulcerWorsens.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Betaine HCl — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Betaine HCl third party tested NSF
CapsulesPre-measured Betaine HCl capsules — easiest for travel and consistent daily dosing without scoops or scales.Betaine HCl capsules
PowderBulk unflavored Betaine HCl powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Betaine HCl powder unflavored
Best sellersMost-purchased Betaine HCl products on Amazon — a quick way to see what's reviewed widely before you commit.Betaine HCl best sellerScientific evidence8Show studiesHide studies
Betaine HCl restores gastric acidity in hypochlorhydria
Yago MR, et al.
Crossover trial of betaine HCl during pharmacologically induced hypochlorhydria.
Rapidly lowered gastric pH below 3.
PubMed: Betaine HCl — Improves drug absorption in PPI-induced hypochlorhydria
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