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evidence · mechanism · dose
Supplements/Nootropic

Pramiracetam

Racetam family — increases high-affinity choline uptake.

MemoryCognitive PerformanceBrain & CognitiveFocus

Overview

Racetam family — increases high-affinity choline uptake.

Natural sources
    Common forms

      Mechanism of action

      Enhances hippocampal HACU (high-affinity choline uptake).

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Cognitive benefit in TBI (small trials)

        Limited evidence

        Potential side effects

        Common
        • · Headache (low choline)
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)

            Supplement interactions

            Pairs well with
            • Alpha-GPC
              Prevent choline-deficit headache.
            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            400–600 mg BID
            With food?
            With fat

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Nootropic
            Pramiracetam
            Amazon
            Wide selection · fast shipping
            Nootropic
            Pramiracetam
            iHerb
            Global delivery · curated brands
            Nootropic
            Pramiracetam
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTBrain Inj · 1991

            Pramiracetam in post-traumatic memory impairment

            McLean A, et al.

            Small RCT of pramiracetam after TBI.

            Key findings

            Improved memory in head-injured patients.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Pramiracetam — Cognitive benefit in TBI

            Live PubMed search

            Live results for "Pramiracetam Cognitive benefit in TBI" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Pramiracetam and "Cognitive benefit in TBI". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Pramiracetam — randomized controlled trial

            Live PubMed search

            Live results for "Pramiracetam randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Pramiracetam and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Pramiracetam — meta-analysis

            Live PubMed search

            Live results for "Pramiracetam meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Pramiracetam and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Pramiracetam — pharmacokinetics

            Live PubMed search

            Live results for "Pramiracetam pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Pramiracetam and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Pramiracetam — safety adverse events

            Live PubMed search

            Live results for "Pramiracetam safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Pramiracetam and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Pramiracetam — dose response

            Live PubMed search

            Live results for "Pramiracetam dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Pramiracetam and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Pramiracetam — clinical evidence

            Live Scholar search

            Cross-database citation index for Pramiracetam as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.