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evidence · mechanism · dose
Supplements/Compound

Creatine (Cognitive Dose)

Higher-dose creatine for cognitive performance under stress.

Brain & CognitiveAthletic Performance

Overview

Higher-dose creatine for cognitive performance under stress.

Natural sources
    Common forms

      Forms & variants of Creatine Monohydrate

      Different chemical forms of Creatine Monohydrate behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Creatine Monohydrate

      The most-studied and effective ergogenic aid — replenishes ATP via the phosphocreatine system.

      Monohydrate
      Creatine Monohydrate

      Gold-standard creatine form — the most studied supplement in sports science.

      Mechanism of action

      Buffers brain ATP/PCr ratio; particularly helpful under hypoxia or sleep loss.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves cognition during sleep deprivation

        Moderate evidence

        Potential side effects

        Common
        • · Water retention
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            10 g/day
            With food?
            Either

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Creatine (Co…
            Amazon
            Wide selection · fast shipping
            Compound
            Creatine (Co…
            iHerb
            Global delivery · curated brands
            Compound
            Creatine (Co…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTPsychopharmacology · 2006

            Creatine for sleep-deprived cognition

            McMorris T, et al.

            Sleep deprivation trial in 19 subjects.

            Key findings

            Creatine improved reaction time and mood after 24-h sleep loss.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Creatine (Cognitive Dose) — Improves cognition during sleep deprivation

            Live PubMed search

            Live results for "Creatine (Cognitive Dose) Improves cognition during sleep deprivation" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Creatine (Cognitive Dose) and "Improves cognition during sleep deprivation". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Creatine (Cognitive Dose) — randomized controlled trial

            Live PubMed search

            Live results for "Creatine (Cognitive Dose) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Creatine (Cognitive Dose) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Creatine (Cognitive Dose) — meta-analysis

            Live PubMed search

            Live results for "Creatine (Cognitive Dose) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Creatine (Cognitive Dose) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Creatine (Cognitive Dose) — pharmacokinetics

            Live PubMed search

            Live results for "Creatine (Cognitive Dose) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Creatine (Cognitive Dose) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Creatine (Cognitive Dose) — safety adverse events

            Live PubMed search

            Live results for "Creatine (Cognitive Dose) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Creatine (Cognitive Dose) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Creatine (Cognitive Dose) — dose response

            Live PubMed search

            Live results for "Creatine (Cognitive Dose) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Creatine (Cognitive Dose) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Creatine (Cognitive Dose) — clinical evidence

            Live Scholar search

            Cross-database citation index for Creatine (Cognitive Dose) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.