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Ziziphus (Jujube Seed)

aka Suan zao ren

Traditional Chinese seed extract for insomnia and anxiety.

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Overview

Traditional Chinese seed extract for insomnia and anxiety.

Natural sources
  • Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
  • Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
  • Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
Common forms
  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Mechanism of action

Saponins (jujubosides) modulate GABA-A and serotonin systems.

Pathways
  • · Saponins (jujubosides) modulate GABA-A
  • · serotonin systems

Effects on the body

Supports
subjective sleep quality

Organ system effects

Brain & CNS

Ziziphus (Jujube Seed) promotes parasympathetic tone, GABAergic signaling, or melatonergic pathways that facilitate sleep onset and quality.

Evidence-based benefits

Improves subjective sleep quality

Limited evidence

Potential side effects

Common
  • · Sedation
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Ziziphus (Jujube Seed) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Avoid / monitor with these medications
      • ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)

      Supplement interactions

      Pairs well with
      • Magnesium glycinate
        Complementary GABAergic calming and improved sleep architecture.
      • L-theanine
        Reduces sleep latency without sedation.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      500–2000 mg
      Best form
      Most evidence is based on the standardized extract capsule form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Evening

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTJ Ethnopharmacol · 2010

      Ziziphus jujuba seed in insomnia

      Cao JX, et al.

      Trial in primary insomnia patients.

      Key findings

      Significantly improved sleep latency and total sleep time vs placebo.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Ziziphus (Jujube Seed) — Improves subjective sleep quality

      Live PubMed search

      Live results for "Ziziphus (Jujube Seed) Improves subjective sleep quality" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Ziziphus (Jujube Seed) and "Improves subjective sleep quality". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Ziziphus (Jujube Seed) — randomized controlled trial

      Live PubMed search

      Live results for "Ziziphus (Jujube Seed) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Ziziphus (Jujube Seed) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Ziziphus (Jujube Seed) — meta-analysis

      Live PubMed search

      Live results for "Ziziphus (Jujube Seed) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Ziziphus (Jujube Seed) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Ziziphus (Jujube Seed) — pharmacokinetics

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      Live results for "Ziziphus (Jujube Seed) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

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      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Ziziphus (Jujube Seed) — safety adverse events

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      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Ziziphus (Jujube Seed) — dose response

      Live PubMed search

      Live results for "Ziziphus (Jujube Seed) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Ziziphus (Jujube Seed) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Ziziphus (Jujube Seed) — clinical evidence

      Live Scholar search

      Cross-database citation index for Ziziphus (Jujube Seed) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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