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evidence · mechanism · dose
Supplements/Herb

Ziziphus (Jujube Seed)

aka Suan zao ren

Traditional Chinese seed extract for insomnia and anxiety.

Sleep & RecoveryMood & Anxiety

Overview

Traditional Chinese seed extract for insomnia and anxiety.

Natural sources
    Common forms

      Mechanism of action

      Saponins (jujubosides) modulate GABA-A and serotonin systems.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves subjective sleep quality

        Limited evidence

        Potential side effects

        Common
        • · Sedation
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)
            Avoid / monitor with these medications
            • ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            500–2000 mg
            With food?
            Evening

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Ziziphus (Ju…
            Amazon
            Wide selection · fast shipping
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            iHerb
            Global delivery · curated brands
            Herb
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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTJ Ethnopharmacol · 2010

            Ziziphus jujuba seed in insomnia

            Cao JX, et al.

            Trial in primary insomnia patients.

            Key findings

            Significantly improved sleep latency and total sleep time vs placebo.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ziziphus (Jujube Seed) — Improves subjective sleep quality

            Live PubMed search

            Live results for "Ziziphus (Jujube Seed) Improves subjective sleep quality" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ziziphus (Jujube Seed) and "Improves subjective sleep quality". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ziziphus (Jujube Seed) — randomized controlled trial

            Live PubMed search

            Live results for "Ziziphus (Jujube Seed) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ziziphus (Jujube Seed) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ziziphus (Jujube Seed) — meta-analysis

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            Live results for "Ziziphus (Jujube Seed) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ziziphus (Jujube Seed) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ziziphus (Jujube Seed) — pharmacokinetics

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            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ziziphus (Jujube Seed) — safety adverse events

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            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ziziphus (Jujube Seed) — dose response

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            Key findings

            Opens current human and preclinical literature matching Ziziphus (Jujube Seed) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Ziziphus (Jujube Seed) — clinical evidence

            Live Scholar search

            Cross-database citation index for Ziziphus (Jujube Seed) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.