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evidence · mechanism · dose
Supplements/Peptide

Semax

Russian nootropic ACTH analog for cognitive enhancement.

Brain & Cognitive

Overview

Russian nootropic ACTH analog for cognitive enhancement.

Natural sources
    Common forms

      Mechanism of action

      Increases BDNF expression and modulates neurotrophins.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves cognition post-stroke

        Moderate evidence

        Potential side effects

        Common
        • · Mild nasal irritation
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)
            Other notes
            • ·Most research peptides are not FDA-approved for human use outside investigational protocols.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            250–600 mcg intranasal

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Peptide
            Semax
            Amazon
            Wide selection · fast shipping
            Peptide
            Semax
            iHerb
            Global delivery · curated brands
            Peptide
            Semax
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTZh Nevrol Psikhiatr · 2005

            Semax in ischemic stroke

            Gusev EI, et al.

            110 stroke patients

            Key findings

            Improved neurological recovery.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Semax — Improves cognition post-stroke

            Live PubMed search

            Live results for "Semax Improves cognition post-stroke" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Semax and "Improves cognition post-stroke". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Semax — randomized controlled trial

            Live PubMed search

            Live results for "Semax randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Semax and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Semax — meta-analysis

            Live PubMed search

            Live results for "Semax meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Semax and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Semax — pharmacokinetics

            Live PubMed search

            Live results for "Semax pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Semax and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Semax — safety adverse events

            Live PubMed search

            Live results for "Semax safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Semax and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Semax — dose response

            Live PubMed search

            Live results for "Semax dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Semax and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Semax — clinical evidence

            Live Scholar search

            Cross-database citation index for Semax as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.