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evidence · mechanism · dose
Supplements/Herb

Salvia officinalis (Sage)

Culinary sage with cholinergic and anti-hyperhidrosis effects.

Brain & CognitiveMenopause Support

Overview

Culinary sage with cholinergic and anti-hyperhidrosis effects.

Natural sources
    Common forms

      Mechanism of action

      Inhibits acetylcholinesterase and modulates muscarinic receptors; thujone reduces sweating.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves cognition in mild AD

        Moderate evidence

        Reduces menopausal hot flashes

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
        • · Seizures with high thujone
        Serious
        • · Avoid high doses in epilepsy/pregnancy

        Drug interactions

        No notable interactions reported.

        Safety & non-supplemental interactions

        Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

        Avoid if you are
        • ·Pregnant or breastfeeding (insufficient safety data)
        • ·Children under 18 (unless directed by a clinician)
        Avoid with these conditions
        • ·Hormone-sensitive cancers (breast, prostate, ovarian, uterine)
        Avoid / monitor with these medications
        • ·Hormonal contraceptives, HRT, tamoxifen, aromatase inhibitors

        Supplement interactions

        Pairs well with

        None listed.

        Avoid combining with

        No specific avoidances listed.

        Dosing & bioavailability

        Typical dose
        300–600 mg extract
        With food?
        With food

        Where to buy

        Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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        Thorne
        Practitioner-grade · NSF tested

        Scientific evidence (9)

        RCTJ Clin Pharm Ther · 2003

        Salvia in mild-moderate AD

        Akhondzadeh S, et al.

        4-month DB-RCT in 42 AD patients.

        Key findings

        Improved cognitive scores vs placebo.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Salvia officinalis (Sage) — Improves cognition in mild AD

        Live PubMed search

        Live results for "Salvia officinalis (Sage) Improves cognition in mild AD" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Salvia officinalis (Sage) and "Improves cognition in mild AD". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Salvia officinalis (Sage) — Reduces menopausal hot flashes

        Live PubMed search

        Live results for "Salvia officinalis (Sage) Reduces menopausal hot flashes" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Salvia officinalis (Sage) and "Reduces menopausal hot flashes". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Salvia officinalis (Sage) — randomized controlled trial

        Live PubMed search

        Live results for "Salvia officinalis (Sage) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Salvia officinalis (Sage) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Salvia officinalis (Sage) — meta-analysis

        Live PubMed search

        Live results for "Salvia officinalis (Sage) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Salvia officinalis (Sage) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Salvia officinalis (Sage) — pharmacokinetics

        Live PubMed search

        Live results for "Salvia officinalis (Sage) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Salvia officinalis (Sage) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Salvia officinalis (Sage) — safety adverse events

        Live PubMed search

        Live results for "Salvia officinalis (Sage) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

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        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Salvia officinalis (Sage) — dose response

        Live PubMed search

        Live results for "Salvia officinalis (Sage) dose response" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Salvia officinalis (Sage) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewGoogle Scholar · 1970

        Google Scholar: Salvia officinalis (Sage) — clinical evidence

        Live Scholar search

        Cross-database citation index for Salvia officinalis (Sage) as it relates to "clinical evidence".

        Key findings

        Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

        Open study
        Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.