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evidence · mechanism · dose
Supplements/Nootropic

Piracetam (Cognitive)

Original racetam used for cortical excitability disorders.

Brain & Cognitive

Overview

Original racetam used for cortical excitability disorders.

Natural sources
    Common forms

      Forms & variants of Piracetam

      Different chemical forms of Piracetam behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Piracetam

      Original racetam; modulates AMPA receptors and membrane fluidity. Rx in many countries.

      Mechanism of action

      Modulates AMPA receptors and membrane fluidity; improves microvascular flow.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces cortical myoclonus

        Strong evidence

        Modest cognitive benefit in dementia

        Moderate evidence

        Potential side effects

        Common
        • · Headache (low choline)
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            1.6 g tid
            With food?
            With meals

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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            Amazon
            Wide selection · fast shipping
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            iHerb
            Global delivery · curated brands
            Nootropic
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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (9)

            Meta-analysisDement Geriatr Cogn Disord · 2002

            Piracetam meta-analysis in dementia

            Waegemans T, et al.

            Pooled 19 RCTs in dementia.

            Key findings

            Significant global improvement vs placebo.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Piracetam (Cognitive) — Reduces cortical myoclonus

            Live PubMed search

            Live results for "Piracetam (Cognitive) Reduces cortical myoclonus" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Piracetam (Cognitive) and "Reduces cortical myoclonus". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Piracetam (Cognitive) — Modest cognitive benefit in dementia

            Live PubMed search

            Live results for "Piracetam (Cognitive) Modest cognitive benefit in dementia" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Piracetam (Cognitive) and "Modest cognitive benefit in dementia". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Piracetam (Cognitive) — randomized controlled trial

            Live PubMed search

            Live results for "Piracetam (Cognitive) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Piracetam (Cognitive) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Piracetam (Cognitive) — meta-analysis

            Live PubMed search

            Live results for "Piracetam (Cognitive) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Piracetam (Cognitive) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Piracetam (Cognitive) — pharmacokinetics

            Live PubMed search

            Live results for "Piracetam (Cognitive) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Piracetam (Cognitive) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Piracetam (Cognitive) — safety adverse events

            Live PubMed search

            Live results for "Piracetam (Cognitive) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Piracetam (Cognitive) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Piracetam (Cognitive) — dose response

            Live PubMed search

            Live results for "Piracetam (Cognitive) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Piracetam (Cognitive) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Piracetam (Cognitive) — clinical evidence

            Live Scholar search

            Cross-database citation index for Piracetam (Cognitive) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.