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evidence · mechanism · dose
Supplements/Compound

Guanfacine (Ref)

α2A-agonist reference drug for prefrontal focus and ADHD.

Brain & Cognitive

Overview

α2A-agonist reference drug for prefrontal focus and ADHD.

Natural sources
    Common forms

      Mechanism of action

      Selective postsynaptic α2A-adrenergic agonism strengthens prefrontal network connectivity.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves ADHD symptoms

        Strong evidence

        Potential side effects

        Common
        • · Sedation
        • · Hypotension
        Rare
        • · Bradycardia
        Serious
        • · Syncope on abrupt discontinuation

        Drug interactions

        No notable interactions reported.

        Supplement interactions

        Pairs well with

        None listed.

        Avoid combining with

        No specific avoidances listed.

        Dosing & bioavailability

        Typical dose
        Rx 1–4 mg/day

        Where to buy

        Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

        Compound
        Guanfacine (…
        Amazon
        Wide selection · fast shipping
        Compound
        Guanfacine (…
        iHerb
        Global delivery · curated brands
        Compound
        Guanfacine (…
        Thorne
        Practitioner-grade · NSF tested

        Scientific evidence (8)

        RCTPediatrics · 2008

        Extended-release guanfacine in pediatric ADHD

        Biederman J, et al.

        8-week RCT in 345 children.

        Key findings

        Significant dose-dependent improvement on ADHD-RS-IV.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Guanfacine (Ref) — Improves ADHD symptoms

        Live PubMed search

        Live results for "Guanfacine (Ref) Improves ADHD symptoms" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Guanfacine (Ref) and "Improves ADHD symptoms". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Guanfacine (Ref) — randomized controlled trial

        Live PubMed search

        Live results for "Guanfacine (Ref) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Guanfacine (Ref) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Guanfacine (Ref) — meta-analysis

        Live PubMed search

        Live results for "Guanfacine (Ref) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Guanfacine (Ref) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Guanfacine (Ref) — pharmacokinetics

        Live PubMed search

        Live results for "Guanfacine (Ref) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Guanfacine (Ref) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Guanfacine (Ref) — safety adverse events

        Live PubMed search

        Live results for "Guanfacine (Ref) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Guanfacine (Ref) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Guanfacine (Ref) — dose response

        Live PubMed search

        Live results for "Guanfacine (Ref) dose response" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Guanfacine (Ref) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewGoogle Scholar · 1970

        Google Scholar: Guanfacine (Ref) — clinical evidence

        Live Scholar search

        Cross-database citation index for Guanfacine (Ref) as it relates to "clinical evidence".

        Key findings

        Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

        Open study
        Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.