Overview
α2A-agonist reference drug for prefrontal focus and ADHD.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Selective postsynaptic α2A-adrenergic agonism strengthens prefrontal network connectivity.
- · Selective postsynaptic α2A-adrenergic agonism strengthens prefrontal network connectivity
Effects on the body
Organ system effects
Guanfacine (Ref) acts on central nervous system targets implicated in attention, memory, and neuroprotection.
Evidence-based benefits
Improves ADHD symptoms
Strong evidencePotential side effects
- · Sedation
- · Hypotension
- · Bradycardia
- · Syncope on abrupt discontinuation
Drug interactions
Supplement interactions
- Omega-3 (EPA/DHA)Membrane fluidity and neuronal signaling support.
- Alpha-GPC or CDP-cholineProvides choline substrate for acetylcholine synthesis.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Guanfacine (Ref) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Guanfacine (Ref) third party tested NSF
CapsulesPre-measured Guanfacine (Ref) capsules — easiest for travel and consistent daily dosing without scoops or scales.Guanfacine (Ref) capsules
PowderBulk unflavored Guanfacine (Ref) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Guanfacine (Ref) powder unflavored
Best sellersMost-purchased Guanfacine (Ref) products on Amazon — a quick way to see what's reviewed widely before you commit.Guanfacine (Ref) best sellerScientific evidence8Show studiesHide studies
Extended-release guanfacine in pediatric ADHD
Biederman J, et al.
8-week RCT in 345 children.
Significant dose-dependent improvement on ADHD-RS-IV.
PubMed: Guanfacine (Ref) — Improves ADHD symptoms
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