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evidence · mechanism · dose
Supplements/Nootropic

Noopept (High-Dose)

Russian dipeptide claimed to enhance BDNF and NGF.

Brain & Cognitive

Overview

Russian dipeptide claimed to enhance BDNF and NGF.

Natural sources
    Common forms

      Forms & variants of Noopept

      Different chemical forms of Noopept behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Noopept

      Synthetic dipeptide (peptide-like) studied for cognition and neuroprotection; not FDA approved.

      Parent
      Noopept

      Synthetic peptide with NGF/BDNF-raising activity at very low doses.

      Mechanism of action

      Modulates AMPA/NMDA receptors and increases neurotrophic factor expression.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves cognition in post-stroke patients (Russian trials)

        Limited evidence

        Potential side effects

        Common
        • · Headache
        • · Irritability
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            10–30 mg
            With food?
            Either

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Nootropic
            Noopept (Hig…
            Amazon
            Wide selection · fast shipping
            Nootropic
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            iHerb
            Global delivery · curated brands
            Nootropic
            Noopept (Hig…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTNeurosci Behav Physiol · 2009

            Noopept in post-stroke cognition

            Neznamov GG, et al.

            8-week trial in post-stroke patients.

            Key findings

            Improved cognitive scores vs piracetam.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Noopept (High-Dose) — Improves cognition in post-stroke patients

            Live PubMed search

            Live results for "Noopept (High-Dose) Improves cognition in post-stroke patients" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Noopept (High-Dose) and "Improves cognition in post-stroke patients". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Noopept (High-Dose) — randomized controlled trial

            Live PubMed search

            Live results for "Noopept (High-Dose) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Noopept (High-Dose) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Noopept (High-Dose) — meta-analysis

            Live PubMed search

            Live results for "Noopept (High-Dose) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Noopept (High-Dose) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Noopept (High-Dose) — pharmacokinetics

            Live PubMed search

            Live results for "Noopept (High-Dose) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Noopept (High-Dose) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Noopept (High-Dose) — safety adverse events

            Live PubMed search

            Live results for "Noopept (High-Dose) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Noopept (High-Dose) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Noopept (High-Dose) — dose response

            Live PubMed search

            Live results for "Noopept (High-Dose) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Noopept (High-Dose) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Noopept (High-Dose) — clinical evidence

            Live Scholar search

            Cross-database citation index for Noopept (High-Dose) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.