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evidence · mechanism · dose
Supplements/Nootropic

Noopept

Synthetic dipeptide (peptide-like) studied for cognition and neuroprotection; not FDA approved.

Brain & Cognitive

Overview

Synthetic dipeptide (peptide-like) studied for cognition and neuroprotection; not FDA approved.

Natural sources
  • Synthetic
Common forms
  • Noopept capsule/powder

Forms & variants of Noopept

Different chemical forms of Noopept behave differently. Browse each form's mechanism, bioavailability, and best-use context.

Cognitive dose
Noopept (High-Dose)

Russian dipeptide claimed to enhance BDNF and NGF.

Mechanism of action

May increase NGF/BDNF and modulate AMPA receptors.

Pathways
  • · BDNF ↑
  • · AMPA modulation

Effects on the body

Supports
Memory consolidation

Organ system effects

Brain & CNS

Russian studies show cognitive improvement post-stroke.

Evidence-based benefits

Improves cognition after vascular events (Russian RCTs)

Limited evidence

Potential side effects

Common
  • · Headache
  • · Irritability
Rare
    Serious

      Drug interactions

      No notable interactions reported.

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)

      Supplement interactions

      Pairs well with

      None listed.

      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      10–30 mg sublingual

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Nootropic
      Noopept
      Amazon
      Wide selection · fast shipping
      Nootropic
      Noopept
      iHerb
      Global delivery · curated brands
      Nootropic
      Noopept
      Thorne
      Practitioner-grade · NSF tested

      Scientific evidence (8)

      RCTNeurosci Behav Physiol · 2009

      Noopept in cognitive disorders after stroke

      Neznamov GG, Teleshova ES

      RCT of noopept in post-stroke cognitive impairment.

      Key findings

      Improved cognition and mood.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Noopept — Improves cognition after vascular events

      Live PubMed search

      Live results for "Noopept Improves cognition after vascular events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Noopept and "Improves cognition after vascular events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Noopept — randomized controlled trial

      Live PubMed search

      Live results for "Noopept randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Noopept and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Noopept — meta-analysis

      Live PubMed search

      Live results for "Noopept meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Noopept and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Noopept — pharmacokinetics

      Live PubMed search

      Live results for "Noopept pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Noopept and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Noopept — safety adverse events

      Live PubMed search

      Live results for "Noopept safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Noopept and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Noopept — dose response

      Live PubMed search

      Live results for "Noopept dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Noopept and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Noopept — clinical evidence

      Live Scholar search

      Cross-database citation index for Noopept as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.