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evidence · mechanism · dose
Supplements/Compound

Alpha-GPC (Cholinergic Recovery)

Choline source — supports acetylcholine after stimulant-driven depletion.

Post-Drug Use RecoveryBrain & Cognitive

Overview

Choline source — supports acetylcholine after stimulant-driven depletion.

Natural sources
    Common forms

      Mechanism of action

      Provides choline for acetylcholine synthesis; crosses BBB.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves cognition in cognitive impairment

        Moderate evidence

        Potential side effects

        Common
        • · Headache
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Other notes
            • ·Discuss with a clinician if you have active liver disease or take hepatotoxic medications.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            300–600 mg
            With food?
            Optional

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Alpha-GPC (C…
            Amazon
            Wide selection · fast shipping
            Compound
            Alpha-GPC (C…
            iHerb
            Global delivery · curated brands
            Compound
            Alpha-GPC (C…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Systematic reviewMech Ageing Dev · 2007

            Alpha-GPC and cognition in vascular dementia

            Parnetti L, et al.

            Review of α-GPC clinical trials in dementia.

            Key findings

            Consistent cognitive improvements at 1200 mg/d.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Alpha-GPC (Cholinergic Recovery) — Improves cognition in cognitive impairment

            Live PubMed search

            Live results for "Alpha-GPC (Cholinergic Recovery) Improves cognition in cognitive impairment" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Alpha-GPC (Cholinergic Recovery) and "Improves cognition in cognitive impairment". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Alpha-GPC (Cholinergic Recovery) — randomized controlled trial

            Live PubMed search

            Live results for "Alpha-GPC (Cholinergic Recovery) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Alpha-GPC (Cholinergic Recovery) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Alpha-GPC (Cholinergic Recovery) — meta-analysis

            Live PubMed search

            Live results for "Alpha-GPC (Cholinergic Recovery) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Alpha-GPC (Cholinergic Recovery) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Alpha-GPC (Cholinergic Recovery) — pharmacokinetics

            Live PubMed search

            Live results for "Alpha-GPC (Cholinergic Recovery) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Alpha-GPC (Cholinergic Recovery) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Alpha-GPC (Cholinergic Recovery) — safety adverse events

            Live PubMed search

            Live results for "Alpha-GPC (Cholinergic Recovery) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Alpha-GPC (Cholinergic Recovery) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Alpha-GPC (Cholinergic Recovery) — dose response

            Live PubMed search

            Live results for "Alpha-GPC (Cholinergic Recovery) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Alpha-GPC (Cholinergic Recovery) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Alpha-GPC (Cholinergic Recovery) — clinical evidence

            Live Scholar search

            Cross-database citation index for Alpha-GPC (Cholinergic Recovery) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.