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evidence · mechanism · dose
Supplements/Compound

CBD (Cannabidiol)

Non-intoxicating cannabinoid studied for anxiety, sleep, and seizures.

Mood & AnxietySleep & RecoveryChronic Inflammation

Overview

Non-intoxicating cannabinoid studied for anxiety, sleep, and seizures.

Natural sources
  • Cannabis sativa / hemp
Common forms
  • Full-spectrum oil
  • Broad spectrum
  • Isolate

Mechanism of action

Modulates endocannabinoid tone (FAAH inhibition) and 5-HT1A receptors.

Pathways
  • · FAAH inhibition
  • · 5-HT1A modulation

Effects on the body

Decreases
Anxiety
Decreases
Seizure frequency (Dravet, LGS)

Organ system effects

Brain & CNS

FDA-approved (Epidiolex) for rare epilepsies.

Liver

Hepatotoxicity at high doses.

Evidence-based benefits

Reduces seizures in Dravet/LGS (Epidiolex)

Strong evidence

Reduces social anxiety symptoms

Moderate evidence

Potential side effects

Common
  • · Drowsiness
  • · Diarrhea
  • · Appetite changes
Rare
    Serious
    • · Hepatotoxicity at >20 mg/kg

    Drug interactions

    Warfarin / clobazam / many CYP3A4 substrates
    CYP inhibition.
    severe
    Hepatotoxic drugs
    Additive.
    moderate

    Safety & non-supplemental interactions

    Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

    Avoid / monitor with these medications
    • ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)

    Supplement interactions

    Pairs well with

    None listed.

    Avoid combining with

    No specific avoidances listed.

    Dosing & bioavailability

    Typical dose
    25–75 mg/d general; Epidiolex 10 mg/kg

    Where to buy

    Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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    iHerb
    Global delivery · curated brands
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    Thorne
    Practitioner-grade · NSF tested

    Scientific evidence (9)

    CohortPerm J · 2019

    Cannabidiol for anxiety and sleep disorders

    Shannon S, et al.

    Retrospective case series of CBD in anxiety and sleep.

    Key findings

    Reduced anxiety in 79% and improved sleep in 67%.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: CBD (Cannabidiol) — Reduces seizures in Dravet/LGS

    Live PubMed search

    Live results for "CBD (Cannabidiol) Reduces seizures in Dravet/LGS" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching CBD (Cannabidiol) and "Reduces seizures in Dravet/LGS". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: CBD (Cannabidiol) — Reduces social anxiety symptoms

    Live PubMed search

    Live results for "CBD (Cannabidiol) Reduces social anxiety symptoms" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching CBD (Cannabidiol) and "Reduces social anxiety symptoms". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: CBD (Cannabidiol) — randomized controlled trial

    Live PubMed search

    Live results for "CBD (Cannabidiol) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching CBD (Cannabidiol) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: CBD (Cannabidiol) — meta-analysis

    Live PubMed search

    Live results for "CBD (Cannabidiol) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching CBD (Cannabidiol) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: CBD (Cannabidiol) — pharmacokinetics

    Live PubMed search

    Live results for "CBD (Cannabidiol) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching CBD (Cannabidiol) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: CBD (Cannabidiol) — safety adverse events

    Live PubMed search

    Live results for "CBD (Cannabidiol) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching CBD (Cannabidiol) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: CBD (Cannabidiol) — dose response

    Live PubMed search

    Live results for "CBD (Cannabidiol) dose response" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching CBD (Cannabidiol) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewGoogle Scholar · 1970

    Google Scholar: CBD (Cannabidiol) — clinical evidence

    Live Scholar search

    Cross-database citation index for CBD (Cannabidiol) as it relates to "clinical evidence".

    Key findings

    Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

    Open study
    Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.