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evidence · mechanism · dose
Supplements/Compound

Modafinil (Rx, reference)

Wakefulness-promoting agent — listed for reference only (prescription drug).

FocusADHD SupportCognitive Performance

Overview

Wakefulness-promoting agent — listed for reference only (prescription drug).

Natural sources
    Common forms

      Mechanism of action

      DAT inhibitor; raises hypothalamic histamine and orexin.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves wakefulness and executive function

        Strong evidence

        Potential side effects

        Common
        • · Insomnia
        • · Headache
        Rare
          Serious
          • · SJS (rare)

          Drug interactions

          Hormonal contraceptives
          Reduced contraceptive efficacy.
          severe

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          100–200 mg AM (Rx)
          With food?
          Optional

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

          Compound
          Modafinil (R…
          Amazon
          Wide selection · fast shipping
          Compound
          Modafinil (R…
          iHerb
          Global delivery · curated brands
          Compound
          Modafinil (R…
          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          Systematic reviewEur Neuropsychopharmacol · 2015

          Adrafinil/modafinil for fatigue and cognition

          Battleday RM, Brem AK

          Review of modafinil-class cognitive effects.

          Key findings

          Consistent enhancement of attention and executive function.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Modafinil (Rx, reference) — Improves wakefulness and executive function

          Live PubMed search

          Live results for "Modafinil (Rx, reference) Improves wakefulness and executive function" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Modafinil (Rx, reference) and "Improves wakefulness and executive function". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Modafinil (Rx, reference) — randomized controlled trial

          Live PubMed search

          Live results for "Modafinil (Rx, reference) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Modafinil (Rx, reference) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Modafinil (Rx, reference) — meta-analysis

          Live PubMed search

          Live results for "Modafinil (Rx, reference) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Modafinil (Rx, reference) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Modafinil (Rx, reference) — pharmacokinetics

          Live PubMed search

          Live results for "Modafinil (Rx, reference) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Modafinil (Rx, reference) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Modafinil (Rx, reference) — safety adverse events

          Live PubMed search

          Live results for "Modafinil (Rx, reference) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Modafinil (Rx, reference) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Modafinil (Rx, reference) — dose response

          Live PubMed search

          Live results for "Modafinil (Rx, reference) dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Modafinil (Rx, reference) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Modafinil (Rx, reference) — clinical evidence

          Live Scholar search

          Cross-database citation index for Modafinil (Rx, reference) as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.