Overview
Wakefulness-promoting agent — listed for reference only (prescription drug).
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
DAT inhibitor; raises hypothalamic histamine and orexin.
- · DAT inhibitor
- · raises hypothalamic histamine
Effects on the body
Organ system effects
Evidence-based benefits
Improves wakefulness and executive function
Strong evidencePotential side effects
- · Insomnia
- · Headache
- · SJS (rare)
Drug interactions
Supplement interactions
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Modafinil (Rx, reference) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Modafinil (Rx, reference) third party tested NSF
CapsulesPre-measured Modafinil (Rx, reference) capsules — easiest for travel and consistent daily dosing without scoops or scales.Modafinil (Rx, reference) capsules
PowderBulk unflavored Modafinil (Rx, reference) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Modafinil (Rx, reference) powder unflavored
Best sellersMost-purchased Modafinil (Rx, reference) products on Amazon — a quick way to see what's reviewed widely before you commit.Modafinil (Rx, reference) best sellerScientific evidence8Show studiesHide studies
Adrafinil/modafinil for fatigue and cognition
Battleday RM, Brem AK
Review of modafinil-class cognitive effects.
Consistent enhancement of attention and executive function.
PubMed: Modafinil (Rx, reference) — Improves wakefulness and executive function
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