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evidence · mechanism · dose
Supplements/Herb

Ashwagandha KSM-66

Standardized Withania somnifera root extract for stress.

Mood & Anxiety

Overview

Standardized Withania somnifera root extract for stress.

Natural sources
    Common forms

      Mechanism of action

      Withanolides modulate HPA axis and reduce cortisol.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces cortisol, improves strength

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        • · Drowsiness
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            600 mg KSM-66

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTIndian J Psychol Med · 2012

            KSM-66 in stress

            Chandrasekhar K, et al.

            64 adults

            Key findings

            27.9% reduction in serum cortisol.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ashwagandha KSM-66 — Reduces cortisol, improves strength

            Live PubMed search

            Live results for "Ashwagandha KSM-66 Reduces cortisol, improves strength" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ashwagandha KSM-66 and "Reduces cortisol, improves strength". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ashwagandha KSM-66 — randomized controlled trial

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            Live results for "Ashwagandha KSM-66 randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ashwagandha KSM-66 — meta-analysis

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            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ashwagandha KSM-66 — pharmacokinetics

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ashwagandha KSM-66 — safety adverse events

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ashwagandha KSM-66 — dose response

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            Key findings

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            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Ashwagandha KSM-66 — clinical evidence

            Live Scholar search

            Cross-database citation index for Ashwagandha KSM-66 as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.