Overview
Standardized Withania somnifera root extract for stress.
- Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
- Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
- Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
- Standardized extract capsule
- Liquid tincture (alcohol or glycerin)
- Powdered whole herb
- Traditional decoction or tea
Mechanism of action
Withanolides modulate HPA axis and reduce cortisol.
- · Withanolides modulate HPA axis
- · reduce cortisol
Effects on the body
Organ system effects
Ashwagandha KSM-66 modulates monoaminergic and GABAergic tone relevant to mood and anxiety regulation.
Evidence-based benefits
Reduces cortisol, improves strength
Moderate evidencePotential side effects
- · GI upset
- · Drowsiness
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
Supplement interactions
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Ashwagandha KSM-66 — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Ashwagandha KSM-66 third party tested NSF
CapsulesPre-measured Ashwagandha KSM-66 capsules — easiest for travel and consistent daily dosing without scoops or scales.Ashwagandha KSM-66 capsules
PowderBulk unflavored Ashwagandha KSM-66 powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Ashwagandha KSM-66 powder unflavored
Best sellersMost-purchased Ashwagandha KSM-66 products on Amazon — a quick way to see what's reviewed widely before you commit.Ashwagandha KSM-66 best sellerScientific evidence8Show studiesHide studies
KSM-66 in stress
Chandrasekhar K, et al.
64 adults
27.9% reduction in serum cortisol.
PubMed: Ashwagandha KSM-66 — Reduces cortisol, improves strength
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