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Supplements/Amino Acid

Suntheanine

Pharmaceutical-grade L-theanine.

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Overview

Pharmaceutical-grade L-theanine.

Natural sources
  • Dietary protein from animal sources (meat, fish, eggs, dairy) and plant sources (soy, legumes, grains)
  • Free-form amino acid powders and capsules
  • Targeted pre-workout, recovery, or sleep formulations
Common forms
  • Free-form crystalline powder
  • Capsules or tablets
  • Pre-mixed recovery or hydration beverages
  • Time-release formulations

Mechanism of action

Same as L-theanine; >99% purity.

Pathways
  • · Same as L-theanine
  • · >99% purity

Effects on the body

Supports
Promotes relaxation

Organ system effects

Brain & CNS

Suntheanine modulates monoaminergic and GABAergic tone relevant to mood and anxiety regulation.

Evidence-based benefits

Promotes relaxation

Moderate evidence

Potential side effects

Common
  • · Well tolerated
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Suntheanine use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • Omega-3 (EPA/DHA)
        Membrane fluidity and neuronal signaling support.
      • Alpha-GPC or CDP-choline
        Provides choline substrate for acetylcholine synthesis.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      100–200 mg
      Best form
      Most evidence is based on the free-form crystalline powder form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either with or without food.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTBiol Psychol · 2007

      Suntheanine and stress

      Kimura K, et al.

      12 healthy adults

      Key findings

      Reduced stress markers during cognitive task.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Suntheanine — Promotes relaxation

      Live PubMed search

      Live results for "Suntheanine Promotes relaxation" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Suntheanine and "Promotes relaxation". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Suntheanine — randomized controlled trial

      Live PubMed search

      Live results for "Suntheanine randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Suntheanine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Suntheanine — meta-analysis

      Live PubMed search

      Live results for "Suntheanine meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Suntheanine and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Suntheanine — pharmacokinetics

      Live PubMed search

      Live results for "Suntheanine pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Suntheanine and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Suntheanine — safety adverse events

      Live PubMed search

      Live results for "Suntheanine safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Suntheanine and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Suntheanine — dose response

      Live PubMed search

      Live results for "Suntheanine dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Suntheanine and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Suntheanine — clinical evidence

      Live Scholar search

      Cross-database citation index for Suntheanine as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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