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evidence · mechanism · dose
Supplements/Vitamin

Folinic Acid (Leucovorin)

Reduced folate form.

General WellnessBrain & Cognitive

Overview

Reduced folate form.

Natural sources
    Common forms

      Mechanism of action

      Tetrahydrofolate derivative; bypasses DHFR.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Folate antagonist rescue

        Moderate evidence

        Potential side effects

        Common
        • · Well tolerated
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            5–25 mg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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            Vitamin
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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTMol Psychiatry · 2018

            Folinic acid in autism

            Frye RE, et al.

            48 ASD children

            Key findings

            Improved verbal communication.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Folinic Acid (Leucovorin) — Folate antagonist rescue

            Live PubMed search

            Live results for "Folinic Acid (Leucovorin) Folate antagonist rescue" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Folinic Acid (Leucovorin) and "Folate antagonist rescue". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Folinic Acid (Leucovorin) — randomized controlled trial

            Live PubMed search

            Live results for "Folinic Acid (Leucovorin) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Folinic Acid (Leucovorin) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Folinic Acid (Leucovorin) — meta-analysis

            Live PubMed search

            Live results for "Folinic Acid (Leucovorin) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Folinic Acid (Leucovorin) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Folinic Acid (Leucovorin) — pharmacokinetics

            Live PubMed search

            Live results for "Folinic Acid (Leucovorin) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Folinic Acid (Leucovorin) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Folinic Acid (Leucovorin) — safety adverse events

            Live PubMed search

            Live results for "Folinic Acid (Leucovorin) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Folinic Acid (Leucovorin) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Folinic Acid (Leucovorin) — dose response

            Live PubMed search

            Live results for "Folinic Acid (Leucovorin) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Folinic Acid (Leucovorin) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Folinic Acid (Leucovorin) — clinical evidence

            Live Scholar search

            Cross-database citation index for Folinic Acid (Leucovorin) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.