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Lavender Oil (Silexan)

aka Silexan

Oral lavender essential oil with proven anxiolytic effect.

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Overview

Oral lavender essential oil with proven anxiolytic effect.

Natural sources
  • Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
  • Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
  • Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
Common forms
  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Mechanism of action

Linalool modulates voltage-gated calcium channels and 5-HT1A receptors.

Pathways
  • · Linalool modulates voltage-gated calcium channels
  • · 5-HT1A receptors

Effects on the body

Decreases
generalized anxiety comparable to lorazepam

Organ system effects

Brain & CNS

Lavender Oil (Silexan) modulates monoaminergic and GABAergic tone relevant to mood and anxiety regulation.

Evidence-based benefits

Reduces generalized anxiety comparable to lorazepam

Strong evidence

Potential side effects

Common
  • · Eructation/burping
  • · GI upset
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Lavender Oil (Silexan) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Avoid / monitor with these medications
      • ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)

      Supplement interactions

      Pairs well with
      • Magnesium glycinate
        Complementary GABAergic calming and improved sleep architecture.
      • L-theanine
        Reduces sleep latency without sedation.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      80–160 mg Silexan
      Best form
      Most evidence is based on the standardized extract capsule form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      With meal

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTInt J Neuropsychopharmacol · 2014

      Silexan vs paroxetine in GAD

      Kasper S, et al.

      10-week DB-RCT in 539 GAD patients.

      Key findings

      Silexan 160 mg = paroxetine 20 mg, both superior to placebo.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Lavender Oil (Silexan) — Reduces generalized anxiety comparable to lorazepam

      Live PubMed search

      Live results for "Lavender Oil (Silexan) Reduces generalized anxiety comparable to lorazepam" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Lavender Oil (Silexan) and "Reduces generalized anxiety comparable to lorazepam". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Lavender Oil (Silexan) — randomized controlled trial

      Live PubMed search

      Live results for "Lavender Oil (Silexan) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Lavender Oil (Silexan) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Lavender Oil (Silexan) — meta-analysis

      Live PubMed search

      Live results for "Lavender Oil (Silexan) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Lavender Oil (Silexan) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Lavender Oil (Silexan) — pharmacokinetics

      Live PubMed search

      Live results for "Lavender Oil (Silexan) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Lavender Oil (Silexan) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Lavender Oil (Silexan) — safety adverse events

      Live PubMed search

      Live results for "Lavender Oil (Silexan) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Lavender Oil (Silexan) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Lavender Oil (Silexan) — dose response

      Live PubMed search

      Live results for "Lavender Oil (Silexan) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Lavender Oil (Silexan) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Lavender Oil (Silexan) — clinical evidence

      Live Scholar search

      Cross-database citation index for Lavender Oil (Silexan) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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