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evidence · mechanism · dose
Supplements/Herb

Lavender Oil (Silexan)

aka Silexan

Oral lavender essential oil with proven anxiolytic effect.

Mood & AnxietySleep & Recovery

Overview

Oral lavender essential oil with proven anxiolytic effect.

Natural sources
    Common forms

      Mechanism of action

      Linalool modulates voltage-gated calcium channels and 5-HT1A receptors.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces generalized anxiety comparable to lorazepam

        Strong evidence

        Potential side effects

        Common
        • · Eructation/burping
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)
            Avoid / monitor with these medications
            • ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            80–160 mg Silexan
            With food?
            With meal

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Lavender Oil…
            Amazon
            Wide selection · fast shipping
            Herb
            Lavender Oil…
            iHerb
            Global delivery · curated brands
            Herb
            Lavender Oil…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTInt J Neuropsychopharmacol · 2014

            Silexan vs paroxetine in GAD

            Kasper S, et al.

            10-week DB-RCT in 539 GAD patients.

            Key findings

            Silexan 160 mg = paroxetine 20 mg, both superior to placebo.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lavender Oil (Silexan) — Reduces generalized anxiety comparable to lorazepam

            Live PubMed search

            Live results for "Lavender Oil (Silexan) Reduces generalized anxiety comparable to lorazepam" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lavender Oil (Silexan) and "Reduces generalized anxiety comparable to lorazepam". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lavender Oil (Silexan) — randomized controlled trial

            Live PubMed search

            Live results for "Lavender Oil (Silexan) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lavender Oil (Silexan) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lavender Oil (Silexan) — meta-analysis

            Live PubMed search

            Live results for "Lavender Oil (Silexan) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lavender Oil (Silexan) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lavender Oil (Silexan) — pharmacokinetics

            Live PubMed search

            Live results for "Lavender Oil (Silexan) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lavender Oil (Silexan) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lavender Oil (Silexan) — safety adverse events

            Live PubMed search

            Live results for "Lavender Oil (Silexan) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lavender Oil (Silexan) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lavender Oil (Silexan) — dose response

            Live PubMed search

            Live results for "Lavender Oil (Silexan) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lavender Oil (Silexan) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Lavender Oil (Silexan) — clinical evidence

            Live Scholar search

            Cross-database citation index for Lavender Oil (Silexan) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.