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Supplements/Compound

MCT C8 (Caprylic Acid)

Pure C8 medium-chain triglyceride for ketone production.

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Overview

Pure C8 medium-chain triglyceride for ketone production.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

Rapidly oxidized to ketones via liver beta-oxidation.

Pathways
  • · Rapidly oxidized to ketones via liver beta-oxidation

Effects on the body

Increases
blood ketones

Organ system effects

Liver

MCT C8 (Caprylic Acid) affects hepatic insulin sensitivity, lipid handling, or glucose disposal.

Brain & CNS

MCT C8 (Caprylic Acid) acts on central nervous system targets implicated in attention, memory, and neuroprotection.

Evidence-based benefits

Raises blood ketones

Moderate evidence

Potential side effects

Common
  • · GI upset
  • · Diarrhea
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose MCT C8 (Caprylic Acid) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • Omega-3 (EPA/DHA)
        Membrane fluidity and neuronal signaling support.
      • Alpha-GPC or CDP-choline
        Provides choline substrate for acetylcholine synthesis.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      10–30 g
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      With a meal containing fat for fat-soluble compounds; otherwise either.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTJ Nutr · 2017

      C8 MCT ketogenesis

      Vandenberghe C, et al.

      Healthy adults

      Key findings

      C8 produced 3-fold higher ketones than C8:C10 blend.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: MCT C8 (Caprylic Acid) — Raises blood ketones

      Live PubMed search

      Live results for "MCT C8 (Caprylic Acid) Raises blood ketones" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching MCT C8 (Caprylic Acid) and "Raises blood ketones". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: MCT C8 (Caprylic Acid) — randomized controlled trial

      Live PubMed search

      Live results for "MCT C8 (Caprylic Acid) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching MCT C8 (Caprylic Acid) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: MCT C8 (Caprylic Acid) — meta-analysis

      Live PubMed search

      Live results for "MCT C8 (Caprylic Acid) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching MCT C8 (Caprylic Acid) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: MCT C8 (Caprylic Acid) — pharmacokinetics

      Live PubMed search

      Live results for "MCT C8 (Caprylic Acid) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching MCT C8 (Caprylic Acid) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: MCT C8 (Caprylic Acid) — safety adverse events

      Live PubMed search

      Live results for "MCT C8 (Caprylic Acid) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching MCT C8 (Caprylic Acid) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: MCT C8 (Caprylic Acid) — dose response

      Live PubMed search

      Live results for "MCT C8 (Caprylic Acid) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching MCT C8 (Caprylic Acid) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: MCT C8 (Caprylic Acid) — clinical evidence

      Live Scholar search

      Cross-database citation index for MCT C8 (Caprylic Acid) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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