SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Herb

Lemon Balm Melissa Officinalis (Bluenesse)

Standardized Melissa for cognition.

Buy
Quick picks · code supplementsch-20 auto-appliedSee all →
Third-party testedThird-party testedAmazon →CapsulesCapsulesAmazon →PowderPowderAmazon →Best sellersBest sellersAmazon →
Brain & CognitiveMood & Anxiety

Overview

Standardized Melissa for cognition.

Natural sources
  • Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
  • Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
  • Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
Common forms
  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Mechanism of action

Rosmarinic acid for AChE and mood.

Pathways
  • · Rosmarinic acid for AChE

Effects on the body

Supports
Cognitive support

Organ system effects

Brain & CNS

Lemon Balm Melissa Officinalis (Bluenesse) acts on central nervous system targets implicated in attention, memory, and neuroprotection.

Evidence-based benefits

Cognitive support

Moderate evidence

Potential side effects

Common
  • · Sedation
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Lemon Balm Melissa Officinalis (Bluenesse) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)

      Supplement interactions

      Pairs well with
      • Omega-3 (EPA/DHA)
        Membrane fluidity and neuronal signaling support.
      • Alpha-GPC or CDP-choline
        Provides choline substrate for acetylcholine synthesis.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      300 mg standardized
      Best form
      Most evidence is based on the standardized extract capsule form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either with or without food.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Buy on AmazonCode supplementsch-20 auto-applied
      Suggested products
      Third-party testedThird-party testedIndependently verified Lemon Balm Melissa Officinalis (Bluenesse) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Lemon Balm Melissa Officinalis (Bluenesse) third party tested NSFCapsulesCapsulesPre-measured Lemon Balm Melissa Officinalis (Bluenesse) capsules — easiest for travel and consistent daily dosing without scoops or scales.Lemon Balm Melissa Officinalis (Bluenesse) capsulesPowderPowderBulk unflavored Lemon Balm Melissa Officinalis (Bluenesse) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Lemon Balm Melissa Officinalis (Bluenesse) powder unflavoredBest sellersBest sellersMost-purchased Lemon Balm Melissa Officinalis (Bluenesse) products on Amazon — a quick way to see what's reviewed widely before you commit.Lemon Balm Melissa Officinalis (Bluenesse) best seller
      Scientific evidence8Show studies
      RCTNutrients · 2014

      Bluenesse for cognition

      Scholey A, et al.

      20 healthy adults

      Key findings

      Improved cognitive performance.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Lemon Balm Melissa Officinalis (Bluenesse) — Cognitive support

      Live PubMed search

      Live results for "Lemon Balm Melissa Officinalis (Bluenesse) Cognitive support" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Lemon Balm Melissa Officinalis (Bluenesse) and "Cognitive support". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Lemon Balm Melissa Officinalis (Bluenesse) — randomized controlled trial

      Live PubMed search

      Live results for "Lemon Balm Melissa Officinalis (Bluenesse) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Lemon Balm Melissa Officinalis (Bluenesse) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Lemon Balm Melissa Officinalis (Bluenesse) — meta-analysis

      Live PubMed search

      Live results for "Lemon Balm Melissa Officinalis (Bluenesse) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Lemon Balm Melissa Officinalis (Bluenesse) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Lemon Balm Melissa Officinalis (Bluenesse) — pharmacokinetics

      Live PubMed search

      Live results for "Lemon Balm Melissa Officinalis (Bluenesse) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Lemon Balm Melissa Officinalis (Bluenesse) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Lemon Balm Melissa Officinalis (Bluenesse) — safety adverse events

      Live PubMed search

      Live results for "Lemon Balm Melissa Officinalis (Bluenesse) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Lemon Balm Melissa Officinalis (Bluenesse) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Lemon Balm Melissa Officinalis (Bluenesse) — dose response

      Live PubMed search

      Live results for "Lemon Balm Melissa Officinalis (Bluenesse) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Lemon Balm Melissa Officinalis (Bluenesse) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Lemon Balm Melissa Officinalis (Bluenesse) — clinical evidence

      Live Scholar search

      Cross-database citation index for Lemon Balm Melissa Officinalis (Bluenesse) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

      Community discussion

      (0 threads)

      Share your experience or read what others have tried. Anecdotes are not medical advice.

      Sign in or create a free account to post or reply.
      Loading discussion…