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evidence · mechanism · dose
Supplements/Amino Acid

DL-Phenylalanine (DLPA)

Racemic phenylalanine for pain and mood.

Mood & Anxiety

Overview

Racemic phenylalanine for pain and mood.

Natural sources
    Common forms

      Mechanism of action

      D-isomer inhibits enkephalinase; L-isomer is catecholamine precursor.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        May reduce chronic pain

        Moderate evidence

        Potential side effects

        Common
        • · Headache
        • · Anxiety
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            500–1500 mg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTArch Phys Med Rehabil · 1986

            DLPA in chronic pain

            Walsh NE, et al.

            30 chronic pain patients

            Key findings

            Mixed results vs placebo.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: DL-Phenylalanine (DLPA) — May reduce chronic pain

            Live PubMed search

            Live results for "DL-Phenylalanine (DLPA) May reduce chronic pain" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching DL-Phenylalanine (DLPA) and "May reduce chronic pain". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: DL-Phenylalanine (DLPA) — randomized controlled trial

            Live PubMed search

            Live results for "DL-Phenylalanine (DLPA) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching DL-Phenylalanine (DLPA) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: DL-Phenylalanine (DLPA) — meta-analysis

            Live PubMed search

            Live results for "DL-Phenylalanine (DLPA) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching DL-Phenylalanine (DLPA) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: DL-Phenylalanine (DLPA) — pharmacokinetics

            Live PubMed search

            Live results for "DL-Phenylalanine (DLPA) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching DL-Phenylalanine (DLPA) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: DL-Phenylalanine (DLPA) — safety adverse events

            Live PubMed search

            Live results for "DL-Phenylalanine (DLPA) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching DL-Phenylalanine (DLPA) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: DL-Phenylalanine (DLPA) — dose response

            Live PubMed search

            Live results for "DL-Phenylalanine (DLPA) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching DL-Phenylalanine (DLPA) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: DL-Phenylalanine (DLPA) — clinical evidence

            Live Scholar search

            Cross-database citation index for DL-Phenylalanine (DLPA) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.