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evidence · mechanism · dose
Supplements/Compound

Agmatine Sulfate

Arginine metabolite with NMDA modulation and analgesic properties.

Brain & CognitiveMood & Anxiety

Overview

Arginine metabolite with NMDA modulation and analgesic properties.

Natural sources
    Common forms

      Mechanism of action

      Blocks NMDA receptor, inhibits nitric oxide synthase, modulates imidazoline receptors.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Adjunct for neuropathic pain

        Limited evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            1.25–2.6 g
            With food?
            Empty stomach

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Agmatine Sul…
            Amazon
            Wide selection · fast shipping
            Compound
            Agmatine Sul…
            iHerb
            Global delivery · curated brands
            Compound
            Agmatine Sul…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTPain Medicine · 2010

            Agmatine for neuropathic pain

            Keynan O, et al.

            12-week trial in 61 lumbar radiculopathy patients.

            Key findings

            2.67 g/day agmatine produced clinically meaningful pain reduction vs placebo.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Agmatine Sulfate — Adjunct for neuropathic pain

            Live PubMed search

            Live results for "Agmatine Sulfate Adjunct for neuropathic pain" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Agmatine Sulfate and "Adjunct for neuropathic pain". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Agmatine Sulfate — randomized controlled trial

            Live PubMed search

            Live results for "Agmatine Sulfate randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Agmatine Sulfate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Agmatine Sulfate — meta-analysis

            Live PubMed search

            Live results for "Agmatine Sulfate meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Agmatine Sulfate and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Agmatine Sulfate — pharmacokinetics

            Live PubMed search

            Live results for "Agmatine Sulfate pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Agmatine Sulfate and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Agmatine Sulfate — safety adverse events

            Live PubMed search

            Live results for "Agmatine Sulfate safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Agmatine Sulfate and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Agmatine Sulfate — dose response

            Live PubMed search

            Live results for "Agmatine Sulfate dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Agmatine Sulfate and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Agmatine Sulfate — clinical evidence

            Live Scholar search

            Cross-database citation index for Agmatine Sulfate as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.