Overview
Arginine metabolite with NMDA modulation and analgesic properties.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Blocks NMDA receptor, inhibits nitric oxide synthase, modulates imidazoline receptors.
- · Blocks NMDA receptor, inhibits nitric oxide synthase, modulates imidazoline receptors
Effects on the body
Organ system effects
Agmatine Sulfate acts on central nervous system targets implicated in attention, memory, and neuroprotection.
Evidence-based benefits
Adjunct for neuropathic pain
Limited evidencePotential side effects
- · GI upset
Drug interactions
Supplement interactions
- Omega-3 (EPA/DHA)Membrane fluidity and neuronal signaling support.
- Alpha-GPC or CDP-cholineProvides choline substrate for acetylcholine synthesis.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Agmatine Sulfate — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Agmatine Sulfate third party tested NSF
CapsulesPre-measured Agmatine Sulfate capsules — easiest for travel and consistent daily dosing without scoops or scales.Agmatine Sulfate capsules
PowderBulk unflavored Agmatine Sulfate powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Agmatine Sulfate powder unflavored
Best sellersMost-purchased Agmatine Sulfate products on Amazon — a quick way to see what's reviewed widely before you commit.Agmatine Sulfate best sellerScientific evidence8Show studiesHide studies
Agmatine for neuropathic pain
Keynan O, et al.
12-week trial in 61 lumbar radiculopathy patients.
2.67 g/day agmatine produced clinically meaningful pain reduction vs placebo.
PubMed: Agmatine Sulfate — Adjunct for neuropathic pain
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PubMed: Agmatine Sulfate — randomized controlled trial
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PubMed: Agmatine Sulfate — dose response
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Google Scholar: Agmatine Sulfate — clinical evidence
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