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Supplements/Amino Acid

5-HTP (Post-MDMA Replenishment)

Serotonin precursor — used post-MDMA to support depleted 5-HT stores. Never combine same-day.

Post-Drug Use RecoveryMood & Anxiety

Overview

Serotonin precursor — used post-MDMA to support depleted 5-HT stores. Never combine same-day.

Natural sources
    Common forms

      Mechanism of action

      Crosses BBB and decarboxylates to serotonin, replenishing pre-synaptic pools.

      Pathways
      • · Serotonin synthesis

      Effects on the body

      Organ system effects

      Evidence-based benefits

      Reduces post-MDMA 'comedown' mood drop (anecdotal)

      Anecdotal

      Potential side effects

      Common
      • · Nausea
      Rare
        Serious
        • · Serotonin syndrome if combined with MDMA, SSRIs, or MAOIs

        Drug interactions

        MDMA (same day)
        Risk of serotonin syndrome — wait minimum 24h after use.
        severe
        SSRIs/MAOIs
        Avoid combining.
        severe

        Safety & non-supplemental interactions

        Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

        Other notes
        • ·Discuss with a clinician if you have active liver disease or take hepatotoxic medications.

        Supplement interactions

        Pairs well with
        • EGCG
          Slows 5-HTP peripheral decarboxylation.
        Avoid combining with
        • Active MDMA
          Serotonin syndrome risk — only use 24h+ after, never before/during.

        Dosing & bioavailability

        Typical dose
        100–200 mg starting 24h after MDMA, evening, for 2–5 days
        With food?
        Empty stomach

        Where to buy

        Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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        iHerb
        Global delivery · curated brands
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        Thorne
        Practitioner-grade · NSF tested

        Scientific evidence (8)

        Systematic reviewNeuropsychopharmacology · 2008

        Serotonergic precursors after MDMA: pharmacological review

        de Win MM, et al.

        Review of serotonergic recovery strategies after MDMA.

        Key findings

        5-HTP repletion plausible 24+ h after use; avoid same-day to prevent syndrome.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: 5-HTP (Post-MDMA Replenishment) — Reduces post-MDMA 'comedown' mood drop

        Live PubMed search

        Live results for "5-HTP (Post-MDMA Replenishment) Reduces post-MDMA 'comedown' mood drop" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching 5-HTP (Post-MDMA Replenishment) and "Reduces post-MDMA 'comedown' mood drop". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: 5-HTP (Post-MDMA Replenishment) — randomized controlled trial

        Live PubMed search

        Live results for "5-HTP (Post-MDMA Replenishment) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching 5-HTP (Post-MDMA Replenishment) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: 5-HTP (Post-MDMA Replenishment) — meta-analysis

        Live PubMed search

        Live results for "5-HTP (Post-MDMA Replenishment) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching 5-HTP (Post-MDMA Replenishment) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: 5-HTP (Post-MDMA Replenishment) — pharmacokinetics

        Live PubMed search

        Live results for "5-HTP (Post-MDMA Replenishment) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching 5-HTP (Post-MDMA Replenishment) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: 5-HTP (Post-MDMA Replenishment) — safety adverse events

        Live PubMed search

        Live results for "5-HTP (Post-MDMA Replenishment) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching 5-HTP (Post-MDMA Replenishment) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: 5-HTP (Post-MDMA Replenishment) — dose response

        Live PubMed search

        Live results for "5-HTP (Post-MDMA Replenishment) dose response" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching 5-HTP (Post-MDMA Replenishment) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewGoogle Scholar · 1970

        Google Scholar: 5-HTP (Post-MDMA Replenishment) — clinical evidence

        Live Scholar search

        Cross-database citation index for 5-HTP (Post-MDMA Replenishment) as it relates to "clinical evidence".

        Key findings

        Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

        Open study
        Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.