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evidence · mechanism · dose
Supplements/Compound

Uridine Monophosphate

Pyrimidine that supports synaptic membrane synthesis.

Brain & CognitiveMood & Anxiety

Overview

Pyrimidine that supports synaptic membrane synthesis.

Natural sources
    Common forms

      Mechanism of action

      Combines with choline and omega-3 to form phosphatidylcholine in synapses.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves cognition in MCI when stacked with omega-3 + choline

        Moderate evidence

        Potential side effects

        Common
        • · Headache
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            250–500 mg
            With food?
            Either

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Uridine Mono…
            Amazon
            Wide selection · fast shipping
            Compound
            Uridine Mono…
            iHerb
            Global delivery · curated brands
            Compound
            Uridine Mono…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTAlzheimers Dement · 2010

            Souvenaid medical food in early AD

            Scheltens P, et al.

            12-week DB-RCT in 225 mild AD patients.

            Key findings

            Improved memory performance vs control.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Uridine Monophosphate — Improves cognition in MCI when stacked with omega-3 + choline

            Live PubMed search

            Live results for "Uridine Monophosphate Improves cognition in MCI when stacked with omega-3 + choline" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Uridine Monophosphate and "Improves cognition in MCI when stacked with omega-3 + choline". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Uridine Monophosphate — randomized controlled trial

            Live PubMed search

            Live results for "Uridine Monophosphate randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Uridine Monophosphate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Uridine Monophosphate — meta-analysis

            Live PubMed search

            Live results for "Uridine Monophosphate meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Uridine Monophosphate and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Uridine Monophosphate — pharmacokinetics

            Live PubMed search

            Live results for "Uridine Monophosphate pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Uridine Monophosphate and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Uridine Monophosphate — safety adverse events

            Live PubMed search

            Live results for "Uridine Monophosphate safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Uridine Monophosphate and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Uridine Monophosphate — dose response

            Live PubMed search

            Live results for "Uridine Monophosphate dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Uridine Monophosphate and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Uridine Monophosphate — clinical evidence

            Live Scholar search

            Cross-database citation index for Uridine Monophosphate as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.