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evidence · mechanism · dose
Supplements/Herb

Blue Vervain

Verbena hastata for nervous tension and headache.

Mood & Anxiety

Overview

Verbena hastata for nervous tension and headache.

Natural sources
    Common forms

      Mechanism of action

      Verbenalin and iridoid glycosides with mild anxiolytic action.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Calming nervine

        Moderate evidence

        Potential side effects

        Common
        • · Nausea high dose
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            2–4 mL tincture

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Blue Vervain
            Amazon
            Wide selection · fast shipping
            Herb
            Blue Vervain
            iHerb
            Global delivery · curated brands
            Herb
            Blue Vervain
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Systematic reviewJ Ethnopharmacol · 2006

            Verbena species pharmacology

            Calvo MI

            Pharmacological review

            Key findings

            Documented sedative and antinociceptive effects in rodents.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Blue Vervain — Calming nervine

            Live PubMed search

            Live results for "Blue Vervain Calming nervine" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Blue Vervain and "Calming nervine". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Blue Vervain — randomized controlled trial

            Live PubMed search

            Live results for "Blue Vervain randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Blue Vervain and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Blue Vervain — meta-analysis

            Live PubMed search

            Live results for "Blue Vervain meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Blue Vervain and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Blue Vervain — pharmacokinetics

            Live PubMed search

            Live results for "Blue Vervain pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Blue Vervain and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Blue Vervain — safety adverse events

            Live PubMed search

            Live results for "Blue Vervain safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Blue Vervain and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Blue Vervain — dose response

            Live PubMed search

            Live results for "Blue Vervain dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Blue Vervain and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Blue Vervain — clinical evidence

            Live Scholar search

            Cross-database citation index for Blue Vervain as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.