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evidence · mechanism · dose
Supplements/Compound

Myo-Inositol

aka Inositol

Insulin sensitizer used for PCOS and anxiety/OCD support.

Women's HealthFertilityBlood Sugar ManagementMood & Anxiety

Overview

Insulin sensitizer used for PCOS and anxiety/OCD support.

Natural sources
  • Citrus
  • Beans
  • Whole grains
Common forms
  • Myo-inositol
  • D-chiro-inositol (40:1 with myo)

Mechanism of action

Second messenger in insulin signaling; modulates serotonin signaling.

Pathways
  • · Insulin signaling
  • · 5-HT signaling

Effects on the body

Supports
Insulin sensitivity
Supports
Ovulation in PCOS

Organ system effects

Reproductive

Restores ovulation in PCOS.

Brain & CNS

Reduces panic and OCD symptoms.

Evidence-based benefits

Restores ovulation in PCOS

Strong evidence

Reduces panic disorder symptoms

Moderate evidence

Potential side effects

Common
  • · GI upset (high dose)
Rare
    Serious

      Drug interactions

      Antidiabetics
      Additive.
      minor

      Supplement interactions

      Pairs well with
      • D-chiro-inositol (40:1)
        Combined ratio mimics physiological balance.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      2 g × 2/d (PCOS); 12–18 g for OCD

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Compound
      Myo-Inositol
      Amazon
      Wide selection · fast shipping
      Compound
      Myo-Inositol
      iHerb
      Global delivery · curated brands
      Compound
      Myo-Inositol
      Thorne
      Practitioner-grade · NSF tested

      Scientific evidence (9)

      Meta-analysisEndocr Connect · 2017

      Myo-inositol for PCOS and metabolic markers

      Unfer V, et al.

      Meta-analysis of inositol in PCOS.

      Key findings

      Improved ovulation, insulin sensitivity, and androgen levels.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Myo-Inositol — Restores ovulation in PCOS

      Live PubMed search

      Live results for "Myo-Inositol Restores ovulation in PCOS" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Myo-Inositol and "Restores ovulation in PCOS". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Myo-Inositol — Reduces panic disorder symptoms

      Live PubMed search

      Live results for "Myo-Inositol Reduces panic disorder symptoms" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Myo-Inositol and "Reduces panic disorder symptoms". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Myo-Inositol — randomized controlled trial

      Live PubMed search

      Live results for "Myo-Inositol randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Myo-Inositol and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Myo-Inositol — meta-analysis

      Live PubMed search

      Live results for "Myo-Inositol meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Myo-Inositol and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Myo-Inositol — pharmacokinetics

      Live PubMed search

      Live results for "Myo-Inositol pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Myo-Inositol and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Myo-Inositol — safety adverse events

      Live PubMed search

      Live results for "Myo-Inositol safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Myo-Inositol and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Myo-Inositol — dose response

      Live PubMed search

      Live results for "Myo-Inositol dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Myo-Inositol and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Myo-Inositol — clinical evidence

      Live Scholar search

      Cross-database citation index for Myo-Inositol as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.