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evidence · mechanism · dose
Supplements/Herb

Bacopa Monnieri

aka Brahmi

Ayurvedic nootropic with strong evidence for memory consolidation over 8–12 weeks.

Brain & CognitiveCortisol ManagementMood & Anxiety

Overview

Ayurvedic nootropic with strong evidence for memory consolidation over 8–12 weeks.

Natural sources
  • Bacopa monnieri
Common forms
  • Standardized bacosides (45–55%)
  • CDRI 08

Mechanism of action

Bacosides promote dendrite branching and modulate serotonin/acetylcholine.

Pathways
  • · Dendritic arborization
  • · 5-HT, ACh modulation

Effects on the body

Supports
Memory consolidation
Decreases
Anxiety

Organ system effects

Brain & CNS

Improves recall after 8–12 weeks.

Evidence-based benefits

Improves memory and word recall over 12 weeks

Strong evidence

Potential side effects

Common
  • · GI upset
  • · Increased bowel movements
Rare
    Serious

      Drug interactions

      Thyroid medication
      May increase T4.
      minor
      CYP3A4 substrates
      Mild inhibition.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Avoid / monitor with these medications
      • ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)

      Supplement interactions

      Pairs well with

      None listed.

      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      300–450 mg standardized, with food

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Herb
      Bacopa Monni…
      Amazon
      Wide selection · fast shipping
      Herb
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      iHerb
      Global delivery · curated brands
      Herb
      Bacopa Monni…
      Thorne
      Practitioner-grade · NSF tested

      Scientific evidence (8)

      Meta-analysisJ Ethnopharmacol · 2014

      Bacopa monnieri for cognitive function: a meta-analysis

      Kongkeaw C, et al.

      Meta-analysis of 9 RCTs of Bacopa.

      Key findings

      Improved attention and information processing.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Bacopa Monnieri — Improves memory and word recall over 12 weeks

      Live PubMed search

      Live results for "Bacopa Monnieri Improves memory and word recall over 12 weeks" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Bacopa Monnieri and "Improves memory and word recall over 12 weeks". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Bacopa Monnieri — randomized controlled trial

      Live PubMed search

      Live results for "Bacopa Monnieri randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Bacopa Monnieri and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Bacopa Monnieri — meta-analysis

      Live PubMed search

      Live results for "Bacopa Monnieri meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Bacopa Monnieri and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Bacopa Monnieri — pharmacokinetics

      Live PubMed search

      Live results for "Bacopa Monnieri pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Bacopa Monnieri and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Bacopa Monnieri — safety adverse events

      Live PubMed search

      Live results for "Bacopa Monnieri safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Bacopa Monnieri and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Bacopa Monnieri — dose response

      Live PubMed search

      Live results for "Bacopa Monnieri dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Bacopa Monnieri and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Bacopa Monnieri — clinical evidence

      Live Scholar search

      Cross-database citation index for Bacopa Monnieri as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.