SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Nootropic

Vinpocetine

Periwinkle alkaloid that increases cerebral blood flow.

Brain & Cognitive

Overview

Periwinkle alkaloid that increases cerebral blood flow.

Natural sources
    Common forms

      Mechanism of action

      PDE1 inhibition, Na+ channel blockade, and selective vasodilation of cerebral vessels.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Mild benefit in cerebrovascular insufficiency

        Moderate evidence

        Potential side effects

        Common
        • · Nausea
        • · Headache
        Rare
        • · Hypotension
        Serious
        • · Avoid in pregnancy

        Drug interactions

        Anticoagulants
        Increased bleeding risk.
        moderate

        Safety & non-supplemental interactions

        Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

        Avoid if you are
        • ·Pregnant or breastfeeding (insufficient safety data)
        • ·Children under 18 (unless directed by a clinician)

        Supplement interactions

        Pairs well with

        None listed.

        Avoid combining with

        No specific avoidances listed.

        Dosing & bioavailability

        Typical dose
        10–30 mg
        With food?
        With meals

        Where to buy

        Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

        Nootropic
        Vinpocetine
        Amazon
        Wide selection · fast shipping
        Nootropic
        Vinpocetine
        iHerb
        Global delivery · curated brands
        Nootropic
        Vinpocetine
        Thorne
        Practitioner-grade · NSF tested

        Scientific evidence (8)

        Systematic reviewCochrane Database · 2003

        Vinpocetine in cognitive impairment

        Szatmari SZ, Whitehouse PJ

        Cochrane review of vinpocetine RCTs in dementia.

        Key findings

        Inconclusive overall but signal for short-term cognitive benefit.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Vinpocetine — Mild benefit in cerebrovascular insufficiency

        Live PubMed search

        Live results for "Vinpocetine Mild benefit in cerebrovascular insufficiency" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Vinpocetine and "Mild benefit in cerebrovascular insufficiency". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Vinpocetine — randomized controlled trial

        Live PubMed search

        Live results for "Vinpocetine randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Vinpocetine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Vinpocetine — meta-analysis

        Live PubMed search

        Live results for "Vinpocetine meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Vinpocetine and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Vinpocetine — pharmacokinetics

        Live PubMed search

        Live results for "Vinpocetine pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Vinpocetine and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Vinpocetine — safety adverse events

        Live PubMed search

        Live results for "Vinpocetine safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Vinpocetine and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Vinpocetine — dose response

        Live PubMed search

        Live results for "Vinpocetine dose response" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Vinpocetine and "dose response". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewGoogle Scholar · 1970

        Google Scholar: Vinpocetine — clinical evidence

        Live Scholar search

        Cross-database citation index for Vinpocetine as it relates to "clinical evidence".

        Key findings

        Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

        Open study
        Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.