Overview
Periwinkle alkaloid that increases cerebral blood flow.
- Manufactured pharmaceutical-grade compound
- Standardized botanical extract (for plant-derived nootropics)
- Stack formulations combined with cholinergic or adaptogenic ingredients
- Capsule
- Powder for stacking
- Sublingual tablet
- Liposomal liquid
Mechanism of action
PDE1 inhibition, Na+ channel blockade, and selective vasodilation of cerebral vessels.
- · PDE1 inhibition, Na+ channel blockade
- · and selective vasodilation of cerebral vessels
Effects on the body
Organ system effects
Vinpocetine acts on central nervous system targets implicated in attention, memory, and neuroprotection.
Evidence-based benefits
Mild benefit in cerebrovascular insufficiency
Moderate evidencePotential side effects
- · Nausea
- · Headache
- · Hypotension
- · Avoid in pregnancy
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
Supplement interactions
- Omega-3 (EPA/DHA)Membrane fluidity and neuronal signaling support.
- Alpha-GPC or CDP-cholineProvides choline substrate for acetylcholine synthesis.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Vinpocetine — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Vinpocetine third party tested NSF
CapsulesPre-measured Vinpocetine capsules — easiest for travel and consistent daily dosing without scoops or scales.Vinpocetine capsules
PowderBulk unflavored Vinpocetine powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Vinpocetine powder unflavored
Best sellersMost-purchased Vinpocetine products on Amazon — a quick way to see what's reviewed widely before you commit.Vinpocetine best sellerScientific evidence8Show studiesHide studies
Vinpocetine in cognitive impairment
Szatmari SZ, Whitehouse PJ
Cochrane review of vinpocetine RCTs in dementia.
Inconclusive overall but signal for short-term cognitive benefit.
PubMed: Vinpocetine — Mild benefit in cerebrovascular insufficiency
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PubMed: Vinpocetine — randomized controlled trial
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PubMed: Vinpocetine — meta-analysis
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PubMed: Vinpocetine — dose response
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Google Scholar: Vinpocetine — clinical evidence
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