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evidence · mechanism · dose
Supplements/Mushroom

Lion's Mane (Neuroregeneration)

NGF-upregulating mushroom — included in post-use stacks for neurotrophic support.

Post-Drug Use RecoveryBrain & Cognitive

Overview

NGF-upregulating mushroom — included in post-use stacks for neurotrophic support.

Natural sources
    Common forms

      Mechanism of action

      Hericenones and erinacines stimulate NGF synthesis in astrocytes, supporting axonal repair.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Modest cognitive improvement in mild cognitive impairment

        Limited evidence

        Potential side effects

        Common
          Rare
          • · Skin rash
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)
            Other notes
            • ·Discuss with a clinician if you have active liver disease or take hepatotoxic medications.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            500–1000 mg dual-extract BID
            With food?
            Optional

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Mushroom
            Lion's Mane …
            Amazon
            Wide selection · fast shipping
            Mushroom
            Lion's Mane …
            iHerb
            Global delivery · curated brands
            Mushroom
            Lion's Mane …
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTPhytother Res · 2009

            Improving effects of Hericium erinaceus on mild cognitive impairment

            Mori K, et al.

            16-week RCT of Lion's Mane in 50–80 y olds with MCI.

            Key findings

            Significant cognitive improvement that regressed after discontinuation.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lion's Mane (Neuroregeneration) — Modest cognitive improvement in mild cognitive impairment

            Live PubMed search

            Live results for "Lion's Mane (Neuroregeneration) Modest cognitive improvement in mild cognitive impairment" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lion's Mane (Neuroregeneration) and "Modest cognitive improvement in mild cognitive impairment". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lion's Mane (Neuroregeneration) — randomized controlled trial

            Live PubMed search

            Live results for "Lion's Mane (Neuroregeneration) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lion's Mane (Neuroregeneration) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lion's Mane (Neuroregeneration) — meta-analysis

            Live PubMed search

            Live results for "Lion's Mane (Neuroregeneration) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lion's Mane (Neuroregeneration) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lion's Mane (Neuroregeneration) — pharmacokinetics

            Live PubMed search

            Live results for "Lion's Mane (Neuroregeneration) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lion's Mane (Neuroregeneration) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lion's Mane (Neuroregeneration) — safety adverse events

            Live PubMed search

            Live results for "Lion's Mane (Neuroregeneration) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lion's Mane (Neuroregeneration) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lion's Mane (Neuroregeneration) — dose response

            Live PubMed search

            Live results for "Lion's Mane (Neuroregeneration) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lion's Mane (Neuroregeneration) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Lion's Mane (Neuroregeneration) — clinical evidence

            Live Scholar search

            Cross-database citation index for Lion's Mane (Neuroregeneration) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.