SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Herb

Lemon Balm (Stress)

Melissa officinalis for acute stress and cognitive performance.

Mood & AnxietyBrain & Cognitive

Overview

Melissa officinalis for acute stress and cognitive performance.

Natural sources
    Common forms

      Forms & variants of Lemon Balm

      Different chemical forms of Lemon Balm behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Lemon Balm

      Mild anxiolytic with cognitive calming effects via GABA-T inhibition.

      Parent
      Lemon Balm (Melissa)

      Anxiolytic mint-family herb with GABA-T inhibition.

      Mechanism of action

      Rosmarinic acid inhibits GABA transaminase; modulates muscarinic and nicotinic receptors.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces acute laboratory stress

        Moderate evidence

        Potential side effects

        Common
        • · Drowsiness
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            300–600 mg standardized
            With food?
            Either

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Lemon Balm (…
            Amazon
            Wide selection · fast shipping
            Herb
            Lemon Balm (…
            iHerb
            Global delivery · curated brands
            Herb
            Lemon Balm (…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTPsychosom Med · 2004

            Lemon balm on stress

            Kennedy DO, et al.

            Acute crossover in 18 healthy volunteers.

            Key findings

            600 mg reduced negative effects of stress task and improved calmness.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lemon Balm (Stress) — Reduces acute laboratory stress

            Live PubMed search

            Live results for "Lemon Balm (Stress) Reduces acute laboratory stress" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lemon Balm (Stress) and "Reduces acute laboratory stress". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lemon Balm (Stress) — randomized controlled trial

            Live PubMed search

            Live results for "Lemon Balm (Stress) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lemon Balm (Stress) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lemon Balm (Stress) — meta-analysis

            Live PubMed search

            Live results for "Lemon Balm (Stress) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lemon Balm (Stress) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lemon Balm (Stress) — pharmacokinetics

            Live PubMed search

            Live results for "Lemon Balm (Stress) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lemon Balm (Stress) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lemon Balm (Stress) — safety adverse events

            Live PubMed search

            Live results for "Lemon Balm (Stress) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lemon Balm (Stress) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lemon Balm (Stress) — dose response

            Live PubMed search

            Live results for "Lemon Balm (Stress) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lemon Balm (Stress) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Lemon Balm (Stress) — clinical evidence

            Live Scholar search

            Cross-database citation index for Lemon Balm (Stress) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.