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evidence · mechanism · dose
Supplements/Vitamin

Benfotiamine

Lipid-soluble thiamine derivative with superior tissue penetration — used in diabetic neuropathy.

Blood Sugar ManagementBrain & Cognitive

Overview

Lipid-soluble thiamine derivative with superior tissue penetration — used in diabetic neuropathy.

Natural sources
    Common forms

      Forms & variants of Vitamin B1 (Thiamine)

      Different chemical forms of Vitamin B1 (Thiamine) behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Vitamin B1 (Thiamine)

      Cofactor for carbohydrate metabolism and nerve conduction.

      Mechanism of action

      Activates transketolase, shunting glucose metabolites away from AGE-forming pathways.

      Pathways
      • · Pentose phosphate pathway
      • · AGE reduction

      Effects on the body

      Organ system effects

      Evidence-based benefits

      Reduces diabetic neuropathy symptoms

      Moderate evidence

      Potential side effects

      Common
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            150–300 mg
            Study range
            300–600 mg
            With food?
            With food

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Vitamin
            Benfotiamine
            Amazon
            Wide selection · fast shipping
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            Benfotiamine
            iHerb
            Global delivery · curated brands
            Vitamin
            Benfotiamine
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTExp Clin Endocrinol Diabetes · 2008

            Benfotiamine for diabetic neuropathy

            Stracke H, et al.

            6-week RCT of benfotiamine in diabetic neuropathy.

            Key findings

            Improved neuropathy symptom score and vibration perception.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Benfotiamine — Reduces diabetic neuropathy symptoms

            Live PubMed search

            Live results for "Benfotiamine Reduces diabetic neuropathy symptoms" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Benfotiamine and "Reduces diabetic neuropathy symptoms". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Benfotiamine — randomized controlled trial

            Live PubMed search

            Live results for "Benfotiamine randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Benfotiamine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Benfotiamine — meta-analysis

            Live PubMed search

            Live results for "Benfotiamine meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Benfotiamine and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Benfotiamine — pharmacokinetics

            Live PubMed search

            Live results for "Benfotiamine pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Benfotiamine and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Benfotiamine — safety adverse events

            Live PubMed search

            Live results for "Benfotiamine safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Benfotiamine and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Benfotiamine — dose response

            Live PubMed search

            Live results for "Benfotiamine dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Benfotiamine and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Benfotiamine — clinical evidence

            Live Scholar search

            Cross-database citation index for Benfotiamine as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.