Overview
Racetam acting on high-affinity choline uptake; studied for depression/anxiety.
- Manufactured pharmaceutical-grade compound
- Standardized botanical extract (for plant-derived nootropics)
- Stack formulations combined with cholinergic or adaptogenic ingredients
- Capsule
- Powder for stacking
- Sublingual tablet
- Liposomal liquid
Mechanism of action
Enhances high-affinity choline uptake (HACU) in damaged cholinergic neurons.
- · Enhances high-affinity choline uptake (HACU) in damaged cholinergic neurons
Effects on the body
Organ system effects
Coluracetam acts on central nervous system targets implicated in attention, memory, and neuroprotection.
Evidence-based benefits
Reduced symptoms in generalized anxiety + depression (Phase IIa)
Limited evidencePotential side effects
- · Headache
- · Visual perception changes
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
Supplement interactions
- Omega-3 (EPA/DHA)Membrane fluidity and neuronal signaling support.
- Alpha-GPC or CDP-cholineProvides choline substrate for acetylcholine synthesis.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Coluracetam — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Coluracetam third party tested NSF
CapsulesPre-measured Coluracetam capsules — easiest for travel and consistent daily dosing without scoops or scales.Coluracetam capsules
PowderBulk unflavored Coluracetam powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Coluracetam powder unflavored
Best sellersMost-purchased Coluracetam products on Amazon — a quick way to see what's reviewed widely before you commit.Coluracetam best sellerScientific evidence8Show studiesHide studies
Coluracetam in GAD/MDD
BrainCells Inc.
Phase 2a in treatment-resistant MDD with comorbid GAD.
240 mg/day reduced HAM-A scores vs placebo.
PubMed: Coluracetam — Reduced symptoms in generalized anxiety + depression
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PubMed: Coluracetam — randomized controlled trial
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PubMed: Coluracetam — meta-analysis
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PubMed: Coluracetam — pharmacokinetics
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PubMed: Coluracetam — safety adverse events
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PubMed: Coluracetam — dose response
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Google Scholar: Coluracetam — clinical evidence
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