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evidence · mechanism · dose
Supplements/Nootropic

Coluracetam

Racetam acting on high-affinity choline uptake; studied for depression/anxiety.

Brain & CognitiveMood & Anxiety

Overview

Racetam acting on high-affinity choline uptake; studied for depression/anxiety.

Natural sources
    Common forms

      Mechanism of action

      Enhances high-affinity choline uptake (HACU) in damaged cholinergic neurons.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduced symptoms in generalized anxiety + depression (Phase IIa)

        Limited evidence

        Potential side effects

        Common
        • · Headache
        Rare
        • · Visual perception changes
        Serious

          Drug interactions

          No notable interactions reported.

          Safety & non-supplemental interactions

          Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

          Avoid if you are
          • ·Pregnant or breastfeeding (insufficient safety data)
          • ·Children under 18 (unless directed by a clinician)

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          20–80 mg

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

          Nootropic
          Coluracetam
          Amazon
          Wide selection · fast shipping
          Nootropic
          Coluracetam
          iHerb
          Global delivery · curated brands
          Nootropic
          Coluracetam
          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          RCTPress Release · 2010

          Coluracetam in GAD/MDD

          BrainCells Inc.

          Phase 2a in treatment-resistant MDD with comorbid GAD.

          Key findings

          240 mg/day reduced HAM-A scores vs placebo.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Coluracetam — Reduced symptoms in generalized anxiety + depression

          Live PubMed search

          Live results for "Coluracetam Reduced symptoms in generalized anxiety + depression" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Coluracetam and "Reduced symptoms in generalized anxiety + depression". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Coluracetam — randomized controlled trial

          Live PubMed search

          Live results for "Coluracetam randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Coluracetam and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Coluracetam — meta-analysis

          Live PubMed search

          Live results for "Coluracetam meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Coluracetam and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Coluracetam — pharmacokinetics

          Live PubMed search

          Live results for "Coluracetam pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Coluracetam and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Coluracetam — safety adverse events

          Live PubMed search

          Live results for "Coluracetam safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Coluracetam and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Coluracetam — dose response

          Live PubMed search

          Live results for "Coluracetam dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Coluracetam and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Coluracetam — clinical evidence

          Live Scholar search

          Cross-database citation index for Coluracetam as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.