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evidence · mechanism · dose
Supplements/Herb

Ashwagandha (Cortisol Lowering)

Validated cortisol-lowering adaptogen — ~28% reduction in chronically stressed adults.

Cortisol Management (alias)Cortisol ManagementStress RecoveryAnxiety Support

Overview

Validated cortisol-lowering adaptogen — ~28% reduction in chronically stressed adults.

Natural sources
    Common forms

      Mechanism of action

      HPA dampening via cortisol receptor modulation; GABA-mimetic withanolides.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Lowers cortisol significantly

        Moderate evidence

        Potential side effects

        Common
        • · Drowsiness
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)
            Avoid / monitor with these medications
            • ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            300–600 mg KSM-66/d
            With food?
            Optional

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Ashwagandha …
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            iHerb
            Global delivery · curated brands
            Herb
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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTIndian J Psychol Med · 2012

            Ashwagandha for stress and cortisol

            Chandrasekhar K, et al.

            60-day RCT of KSM-66 in chronic stress.

            Key findings

            Significant reduction in serum cortisol and perceived stress.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ashwagandha (Cortisol Lowering) — Lowers cortisol significantly

            Live PubMed search

            Live results for "Ashwagandha (Cortisol Lowering) Lowers cortisol significantly" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ashwagandha (Cortisol Lowering) and "Lowers cortisol significantly". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ashwagandha (Cortisol Lowering) — randomized controlled trial

            Live PubMed search

            Live results for "Ashwagandha (Cortisol Lowering) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ashwagandha (Cortisol Lowering) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ashwagandha (Cortisol Lowering) — meta-analysis

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            Live results for "Ashwagandha (Cortisol Lowering) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ashwagandha (Cortisol Lowering) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ashwagandha (Cortisol Lowering) — pharmacokinetics

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            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ashwagandha (Cortisol Lowering) — safety adverse events

            Live PubMed search

            Live results for "Ashwagandha (Cortisol Lowering) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ashwagandha (Cortisol Lowering) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ashwagandha (Cortisol Lowering) — dose response

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            Live results for "Ashwagandha (Cortisol Lowering) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ashwagandha (Cortisol Lowering) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Ashwagandha (Cortisol Lowering) — clinical evidence

            Live Scholar search

            Cross-database citation index for Ashwagandha (Cortisol Lowering) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.