Anxiety Support
GABAergic and HPA-calming compounds.
Ranked by evidence strength across reported benefits.
Ashwagandha
Adaptogenic herb that down-regulates HPA-axis output — lowers cortisol, supports T in stressed men.
Vitamin D3
Steroid hormone precursor regulating ~5% of the human genome — bone, immune, and hormonal health.
Omega-3 (EPA/DHA)
Marine long-chain omega-3s — the most-studied anti-inflammatory and cardiovascular nutrient.
L-Theanine
Calm focus — alpha-wave amino acid from green tea that takes the edge off caffeine.
N-Acetyl Cysteine (NAC)
Glutathione precursor with mucolytic, hepatoprotective, and psychiatric uses.
Magnesium Glycinate
Chelated magnesium bound to glycine — best-tolerated form for sleep, calm, and muscle relaxation.
Saffron
Culinary spice with antidepressant effects comparable to SSRIs in mild-moderate depression.
Vitamin B6 (Pyridoxine)
Cofactor for >100 enzymes including neurotransmitter synthesis.
Folate (Vitamin B9)
One-carbon donor essential for DNA synthesis and neural tube development.
Myo-Inositol
Insulin sensitizer used for PCOS and anxiety/OCD support.
CBD (Cannabidiol)
Non-intoxicating cannabinoid studied for anxiety, sleep, and seizures.
Methylfolate (L-5-MTHF)
Bioactive folate that bypasses the MTHFR enzyme — preferred in MTHFR variants and pregnancy.
Methylcobalamin (B12)
Active methyl-form of B12 — directly usable in the methylation cycle.
Kava
Polynesian anxiolytic with strong evidence; rare hepatotoxicity risk.
St. John's Wort
Mild-moderate antidepressant with significant CYP450 drug interactions.
Bacopa Monnieri
Ayurvedic nootropic with strong evidence for memory consolidation over 8–12 weeks.
Lavender Oil (Silexan)
Oral lavender essential oil with proven anxiolytic effect.
EPA-Only Omega-3
Pure EPA reduces residual cardiovascular risk on statins.
Kava (WS-1490)
Standardized kavalactone extract for anxiety.
Chamomile (GAD)
Matricaria recutita standardized extract for generalized anxiety.
Rhodiola Rosea
Arctic adaptogen — reduces fatigue and improves mental performance under stress.
Holy Basil (Tulsi)
Ayurvedic adaptogen with anti-stress, anti-inflammatory, and glycemic effects.
Mucuna Pruriens
Natural L-DOPA source studied for mood, libido, and Parkinson's.
L-Theanine (Sleep)
Tea-derived amino acid that raises alpha brainwaves — relaxation without sedation.
Passionflower
Mild anxiolytic and sleep aid with GABA-A modulation.
Gotu Kola
Adaptogen used for cognitive support, anxiety, and wound healing.
Saffron (Crocus sativus)
Crocin-rich spice with antidepressant effects comparable to SSRIs in mild–moderate depression.
Centella Asiatica (Gotu Kola)
Traditional brain and skin tonic — supports cognition and wound healing.
P-5-P (Pyridoxal-5-Phosphate)
Active coenzyme form of B6 — preferred over pyridoxine HCl for sensitive populations.
Kanna (Sceletium)
South African succulent acting as SSRI + PDE4 inhibitor for mood and stress.
Passionflower (Anxiety)
Passiflora incarnata for mild GAD and pre-surgical anxiety.
L-Tyrosine
Catecholamine precursor preserving cognition under stress and sleep deprivation.
L-Tryptophan
Essential amino acid precursor to serotonin and melatonin.
Chamomile
Gentle anxiolytic and sleep-supportive herb.
Lemon Balm
Mild anxiolytic with cognitive calming effects via GABA-T inhibition.
NAC (Post-Use Recovery)
GSH precursor — supports glutamatergic rebalancing and oxidative stress recovery after stimulant or psychedelic use.
Ashwagandha (Cortisol Lowering)
Validated cortisol-lowering adaptogen — ~28% reduction in chronically stressed adults.
Holy Basil (Tulsi)
Sacred basil adaptogen — anti-stress and mild glucose-lowering effects.
Sensoril Ashwagandha
Root + leaf extract standardized to ≥10% withanolides — higher potency, more sedating.
Magnolia Bark
GABAergic anxiolytic bark extract used for sleep and stress.
Bifidobacterium longum 1714
Psychobiotic strain shown to reduce stress and improve memory.
Lemon Balm (Stress)
Melissa officinalis for acute stress and cognitive performance.
Uridine Monophosphate
Pyrimidine that supports synaptic membrane synthesis.
5-HTP (Mood Dose)
Serotonin precursor used for mild depression and migraine.
L-Tryptophan (Sleep)
Direct serotonin/melatonin precursor for nocturnal use.
GABA (Pharma-grade)
Fermented GABA with reported peripheral relaxation effects.
Valerian (Sleep)
Valeriana officinalis root extract for sleep latency.
Rosemary (Cognitive)
Rosmarinus officinalis for memory and mood via inhalation or oral.
Holy Basil (Tulsi)
Adaptogenic basil used for stress and blood sugar.
Blue Vervain
Verbena hastata for nervous tension and headache.
California Poppy
Eschscholzia californica for anxiety and insomnia.
Mulungu
Erythrina mulungu bark for anxiety relief.
Selank
Russian anxiolytic peptide based on tuftsin.
Ashwagandha KSM-66
Standardized Withania somnifera root extract for stress.
Shoden Ashwagandha
35% withanolide glycoside Ashwagandha for sleep.
Mucuna Pruriens
Velvet bean providing natural L-DOPA.
Bifidobacterium Longum 1714
Psychobiotic for stress and mood.
L. helveticus R0052
Psychobiotic blend component for mood.
L-Phenylalanine
Precursor to tyrosine and catecholamines.
DL-Phenylalanine (DLPA)
Racemic phenylalanine for pain and mood.
BCM-95 Curcumin
Curcumin with turmeric oils for absorption.
Baicalin
Scutellaria baicalensis flavonoid.
Rhodiola SHR-5
Standardized Rhodiola for fatigue.
Myo-Inositol (High-Dose)
High-dose for psychiatric uses.
Suntheanine
Pharmaceutical-grade L-theanine.
PharmaGABA
Naturally fermented GABA.
Picamilon
Niacin-GABA conjugate.
Aniracetam
Fat-soluble racetam.
Holy Basil (Tulsi)
Ocimum sanctum adaptogen.
Ocimum Tenuiflorum (OciBest)
Standardized Holy Basil for stress.
Lemon Balm Melissa Officinalis (Bluenesse)
Standardized Melissa for cognition.
Saffron Affron
Standardized saffron for mood.
Saffron Satiereal
Saffron for appetite and snacking.
Honokiol
Active magnolia compound.
Magnolol
Active magnolia biphenol.
EPA-Dominant Fish Oil
Concentrated EPA for inflammation.
Lion's Mane
Edible medicinal mushroom that upregulates NGF and BDNF — studied for nerve growth and cognition.
5-HTP
Direct serotonin precursor with mood and sleep applications.
Lithium Orotate (low-dose)
Low-dose lithium salt studied for mood stability and neuroprotection.
GABA
Primary inhibitory neurotransmitter; oral supplementation has limited CNS penetration.
Valerian Root
Sedative herb traditionally used for sleep onset and mild anxiety.
Pregnenolone
Master steroid precursor; small doses studied for cognition and PTSD.
Phenibut (caution)
GABA-B agonist with high abuse and dependence potential; restricted in many countries.
Kratom (caution)
Atypical opioid herb with stimulant low-dose and sedating high-dose effects; addiction risk.
Apigenin
Chamomile/parsley flavonoid — GABA-A modulator and CD38 inhibitor for sleep and NAD+.
Valerian Root
GABAergic sedative herb — modest sleep onset benefit.
Passionflower
Anxiolytic herb shown comparable to oxazepam for generalized anxiety.
Lemon Balm (Melissa)
Anxiolytic mint-family herb with GABA-T inhibition.
Agmatine Sulfate
Arginine metabolite with NMDA modulation and analgesic properties.
Coluracetam
Racetam acting on high-affinity choline uptake; studied for depression/anxiety.
Chinese Skullcap
Flavonoid-rich root used for anxiety and inflammation.
California Poppy
Mild sedative with anxiolytic and analgesic activity.
Ziziphus (Jujube Seed)
Traditional Chinese seed extract for insomnia and anxiety.
Magnesium Acetyl-Taurate
Brain-penetrant Mg form combined with taurate for mood.
DL-Phenylalanine
Catecholamine precursor with mild analgesic properties.
Phenibut (Ref)
GABA-B agonist developed in the USSR for anxiety (caution).
5-HTP (Post-MDMA Replenishment)
Serotonin precursor — used post-MDMA to support depleted 5-HT stores. Never combine same-day.