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Supplements/Compound

Bifidobacterium Longum 1714

Psychobiotic for stress and mood.

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Overview

Psychobiotic for stress and mood.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

Modulates HPA axis via vagus nerve.

Pathways
  • · Modulates HPA axis via vagus nerve

Effects on the body

Decreases
stress response

Organ system effects

Brain & CNS

Bifidobacterium Longum 1714 modulates monoaminergic and GABAergic tone relevant to mood and anxiety regulation.

Digestive / Gut

Bifidobacterium Longum 1714 influences gut motility, mucosal integrity, or microbial balance in the GI tract.

Evidence-based benefits

Reduces stress response

Moderate evidence

Potential side effects

Common
  • · Mild GI
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Bifidobacterium Longum 1714 use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • Multi-strain probiotic
        Supports microbiome diversity and barrier integrity.
      • L-glutamine
        Substrate for enterocyte energy and tight-junction maintenance.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      1 billion CFU
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      With a meal containing fat for fat-soluble compounds; otherwise either.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTTransl Psychiatry · 2016

      B. longum 1714 stress

      Allen AP, et al.

      22 healthy men

      Key findings

      Reduced cortisol and improved memory.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Bifidobacterium Longum 1714 — Reduces stress response

      Live PubMed search

      Live results for "Bifidobacterium Longum 1714 Reduces stress response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Bifidobacterium Longum 1714 and "Reduces stress response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Bifidobacterium Longum 1714 — randomized controlled trial

      Live PubMed search

      Live results for "Bifidobacterium Longum 1714 randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Bifidobacterium Longum 1714 and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Bifidobacterium Longum 1714 — meta-analysis

      Live PubMed search

      Live results for "Bifidobacterium Longum 1714 meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Bifidobacterium Longum 1714 and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Bifidobacterium Longum 1714 — pharmacokinetics

      Live PubMed search

      Live results for "Bifidobacterium Longum 1714 pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Bifidobacterium Longum 1714 and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Bifidobacterium Longum 1714 — safety adverse events

      Live PubMed search

      Live results for "Bifidobacterium Longum 1714 safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Bifidobacterium Longum 1714 and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Bifidobacterium Longum 1714 — dose response

      Live PubMed search

      Live results for "Bifidobacterium Longum 1714 dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Bifidobacterium Longum 1714 and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Bifidobacterium Longum 1714 — clinical evidence

      Live Scholar search

      Cross-database citation index for Bifidobacterium Longum 1714 as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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