Overview
Niacin-GABA conjugate.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Crosses BBB, hydrolyzed to niacin + GABA.
- · Crosses BBB, hydrolyzed to niacin + GABA
Effects on the body
Organ system effects
Picamilon modulates monoaminergic and GABAergic tone relevant to mood and anxiety regulation.
Evidence-based benefits
Mild anxiolytic
Moderate evidencePotential side effects
- · Headache
Drug interactions
Supplement interactions
- Omega-3 (EPA/DHA)Membrane fluidity and neuronal signaling support.
- Alpha-GPC or CDP-cholineProvides choline substrate for acetylcholine synthesis.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Picamilon — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Picamilon third party tested NSF
CapsulesPre-measured Picamilon capsules — easiest for travel and consistent daily dosing without scoops or scales.Picamilon capsules
PowderBulk unflavored Picamilon powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Picamilon powder unflavored
Best sellersMost-purchased Picamilon products on Amazon — a quick way to see what's reviewed widely before you commit.Picamilon best sellerScientific evidence8Show studiesHide studies
Picamilon in cerebrovascular disease
Mirzoian RS, et al.
Cerebrovascular model
Improved cerebral blood flow.
PubMed: Picamilon — Mild anxiolytic
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PubMed: Picamilon — randomized controlled trial
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PubMed: Picamilon — meta-analysis
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PubMed: Picamilon — dose response
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Google Scholar: Picamilon — clinical evidence
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