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evidence · mechanism · dose
Supplements/Compound

Apigenin

Chamomile/parsley flavonoid — GABA-A modulator and CD38 inhibitor for sleep and NAD+.

Sleep QualityDeep Sleep (SWS)Anxiety SupportNAD+ Support

Overview

Chamomile/parsley flavonoid — GABA-A modulator and CD38 inhibitor for sleep and NAD+.

Natural sources
    Common forms

      Mechanism of action

      Positive allosteric modulator of GABA-A α3; inhibits CD38 (NADase) supporting NAD+.

      Pathways
      • · GABA-A modulation
      • · CD38 inhibition

      Effects on the body

      Organ system effects

      Evidence-based benefits

      Reduces anxiety and improves sleep onset

      Limited evidence

      Potential side effects

      Common
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with
            • L-theanine
              Layered GABA modulation.
            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            50 mg pre-bed
            With food?
            Optional

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Apigenin
            Amazon
            Wide selection · fast shipping
            Compound
            Apigenin
            iHerb
            Global delivery · curated brands
            Compound
            Apigenin
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTPhytomedicine · 2016

            Chamomile and apigenin for generalized anxiety disorder

            Mao JJ, et al.

            12-week RCT of chamomile extract (rich in apigenin) in GAD.

            Key findings

            Significant reduction in GAD-7 scores.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Apigenin — Reduces anxiety and improves sleep onset

            Live PubMed search

            Live results for "Apigenin Reduces anxiety and improves sleep onset" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Apigenin and "Reduces anxiety and improves sleep onset". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Apigenin — randomized controlled trial

            Live PubMed search

            Live results for "Apigenin randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Apigenin and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Apigenin — meta-analysis

            Live PubMed search

            Live results for "Apigenin meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Apigenin and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Apigenin — pharmacokinetics

            Live PubMed search

            Live results for "Apigenin pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Apigenin and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Apigenin — safety adverse events

            Live PubMed search

            Live results for "Apigenin safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Apigenin and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Apigenin — dose response

            Live PubMed search

            Live results for "Apigenin dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Apigenin and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Apigenin — clinical evidence

            Live Scholar search

            Cross-database citation index for Apigenin as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.