Deep Sleep (SWS)
Slow-wave sleep enhancement.
Ranked by evidence strength across reported benefits.
Magnesium
Essential cofactor in 300+ enzymatic reactions, from ATP production to muscle relaxation.
Ashwagandha
Adaptogenic herb that down-regulates HPA-axis output — lowers cortisol, supports T in stressed men.
Melatonin
Pineal hormone that signals biological night — most effective for circadian-rhythm shifts.
L-Theanine
Calm focus — alpha-wave amino acid from green tea that takes the edge off caffeine.
Magnesium Glycinate
Chelated magnesium bound to glycine — best-tolerated form for sleep, calm, and muscle relaxation.
CBD (Cannabidiol)
Non-intoxicating cannabinoid studied for anxiety, sleep, and seizures.
Glycine
Inhibitory amino acid that improves sleep quality, glycemic control, and collagen synthesis.
Melatonin (low-dose physiologic)
Endogenous sleep hormone; low doses (0.3–0.5 mg) typically outperform mega-doses.
Lavender Oil (Silexan)
Oral lavender essential oil with proven anxiolytic effect.
Kava (WS-1490)
Standardized kavalactone extract for anxiety.
Chamomile (GAD)
Matricaria recutita standardized extract for generalized anxiety.
Glycine
Inhibitory neurotransmitter that improves sleep quality and supports collagen synthesis.
KSM-66 Ashwagandha
Root-only standardized ashwagandha extract — the most-studied form for stress and T-support.
Passionflower
Mild anxiolytic and sleep aid with GABA-A modulation.
Reishi
Adaptogenic mushroom used for immune balance, sleep, and stress.
Magnesium L-Threonate
Magnesium bound to L-threonic acid — the only form shown to meaningfully raise brain magnesium.
Passionflower (Anxiety)
Passiflora incarnata for mild GAD and pre-surgical anxiety.
L-Tryptophan
Essential amino acid precursor to serotonin and melatonin.
Chamomile
Gentle anxiolytic and sleep-supportive herb.
Lemon Balm
Mild anxiolytic with cognitive calming effects via GABA-T inhibition.
Magnesium Glycinate
Bisglycinate chelate form of magnesium — gentle, well-absorbed, ideal for sleep.
Glycine (Sleep Onset)
3 g pre-bed lowers core body temperature and improves subjective sleep.
Sensoril Ashwagandha
Root + leaf extract standardized to ≥10% withanolides — higher potency, more sedating.
Magnolia Bark
GABAergic anxiolytic bark extract used for sleep and stress.
Hops Extract
Bitter cone extract with mild sedative and phytoestrogenic effects.
L-Tryptophan (Sleep)
Direct serotonin/melatonin precursor for nocturnal use.
GABA (Pharma-grade)
Fermented GABA with reported peripheral relaxation effects.
Valerian (Sleep)
Valeriana officinalis root extract for sleep latency.
California Poppy
Eschscholzia californica for anxiety and insomnia.
Shoden Ashwagandha
35% withanolide glycoside Ashwagandha for sleep.
Poria Cocos
TCM mushroom for sleep and immunity.
PharmaGABA
Naturally fermented GABA.
Zinc Monomethionine (ZMA)
Zinc + magnesium + B6 for recovery.
Saffron Affron
Standardized saffron for mood.
Valerian Root Extract
Valeriana officinalis for sleep.
Valerian + Hops
Sleep blend.
Honokiol
Active magnolia compound.
Micellar Casein
Slow-digesting milk protein.
5-HTP
Direct serotonin precursor with mood and sleep applications.
Magnesium Taurate
Magnesium + taurine — gentle on the gut with cardiovascular and glycemic synergies.
GABA
Primary inhibitory neurotransmitter; oral supplementation has limited CNS penetration.
Valerian Root
Sedative herb traditionally used for sleep onset and mild anxiety.
Phenibut (caution)
GABA-B agonist with high abuse and dependence potential; restricted in many countries.
Magnesium L-Threonate
Mg form designed for brain penetration; studied for cognition and sleep.
L-Ornithine
Urea-cycle amino acid that lowers fatigue and supports nighttime GH release.
Apigenin
Chamomile/parsley flavonoid — GABA-A modulator and CD38 inhibitor for sleep and NAD+.
Valerian Root
GABAergic sedative herb — modest sleep onset benefit.
California Poppy
Mild sedative with anxiolytic and analgesic activity.
Ziziphus (Jujube Seed)
Traditional Chinese seed extract for insomnia and anxiety.