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evidence · mechanism · dose
Supplements/Herb

Magnolia Bark

aka Honokiol · Magnolol

GABAergic anxiolytic bark extract used for sleep and stress.

Sleep & RecoveryMood & Anxiety

Overview

GABAergic anxiolytic bark extract used for sleep and stress.

Natural sources
    Common forms

      Mechanism of action

      Honokiol/magnolol act as positive allosteric modulators at GABA-A and reduce cortisol.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces perceived stress and improves sleep quality

        Moderate evidence

        Potential side effects

        Common
        • · Drowsiness
        Rare
          Serious

            Drug interactions

            CNS depressants
            Additive sedation.
            moderate

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)
            Avoid / monitor with these medications
            • ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            200–400 mg standardized extract
            With food?
            Evening

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Magnolia Bark
            Amazon
            Wide selection · fast shipping
            Herb
            Magnolia Bark
            iHerb
            Global delivery · curated brands
            Herb
            Magnolia Bark
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTJ Int Soc Sports Nutr · 2013

            Magnolia/phellodendron in stress

            Talbott SM, et al.

            DB-RCT in 56 stressed adults.

            Key findings

            Significant cortisol and mood improvement vs placebo over 4 weeks.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Magnolia Bark — Reduces perceived stress and improves sleep quality

            Live PubMed search

            Live results for "Magnolia Bark Reduces perceived stress and improves sleep quality" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Magnolia Bark and "Reduces perceived stress and improves sleep quality". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Magnolia Bark — randomized controlled trial

            Live PubMed search

            Live results for "Magnolia Bark randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Magnolia Bark and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Magnolia Bark — meta-analysis

            Live PubMed search

            Live results for "Magnolia Bark meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Magnolia Bark and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Magnolia Bark — pharmacokinetics

            Live PubMed search

            Live results for "Magnolia Bark pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Magnolia Bark and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Magnolia Bark — safety adverse events

            Live PubMed search

            Live results for "Magnolia Bark safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Magnolia Bark and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Magnolia Bark — dose response

            Live PubMed search

            Live results for "Magnolia Bark dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Magnolia Bark and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Magnolia Bark — clinical evidence

            Live Scholar search

            Cross-database citation index for Magnolia Bark as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.