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evidence · mechanism · dose
Supplements/Amino Acid

Glycine (Sleep Onset)

3 g pre-bed lowers core body temperature and improves subjective sleep.

Sleep QualityDeep Sleep (SWS)Sleep & Recovery

Overview

3 g pre-bed lowers core body temperature and improves subjective sleep.

Natural sources
    Common forms

      Mechanism of action

      Activates suprachiasmatic NMDA receptors → peripheral vasodilation → core temp drop.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves sleep quality and morning alertness

        Moderate evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Safety & non-supplemental interactions

              Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

              Avoid / monitor with these medications
              • ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              3 g pre-bed
              With food?
              Optional

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTSleep Biol Rhythms · 2007

              Glycine ingestion before sleep improves subjective sleep quality

              Yamadera W, et al.

              Crossover trial of 3 g glycine before bed.

              Key findings

              Improved subjective sleep quality and daytime function.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Glycine (Sleep Onset) — Improves sleep quality and morning alertness

              Live PubMed search

              Live results for "Glycine (Sleep Onset) Improves sleep quality and morning alertness" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Glycine (Sleep Onset) and "Improves sleep quality and morning alertness". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Glycine (Sleep Onset) — randomized controlled trial

              Live PubMed search

              Live results for "Glycine (Sleep Onset) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Glycine (Sleep Onset) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Glycine (Sleep Onset) — meta-analysis

              Live PubMed search

              Live results for "Glycine (Sleep Onset) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Glycine (Sleep Onset) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Glycine (Sleep Onset) — pharmacokinetics

              Live PubMed search

              Live results for "Glycine (Sleep Onset) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Glycine (Sleep Onset) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Glycine (Sleep Onset) — safety adverse events

              Live PubMed search

              Live results for "Glycine (Sleep Onset) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Glycine (Sleep Onset) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Glycine (Sleep Onset) — dose response

              Live PubMed search

              Live results for "Glycine (Sleep Onset) dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Glycine (Sleep Onset) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Glycine (Sleep Onset) — clinical evidence

              Live Scholar search

              Cross-database citation index for Glycine (Sleep Onset) as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.