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evidence · mechanism · dose
Supplements/Herb

Passionflower (Anxiety)

Passiflora incarnata for mild GAD and pre-surgical anxiety.

Mood & AnxietySleep & Recovery

Overview

Passiflora incarnata for mild GAD and pre-surgical anxiety.

Natural sources
    Common forms

      Forms & variants of Passionflower

      Different chemical forms of Passionflower behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Passionflower

      Mild anxiolytic and sleep aid with GABA-A modulation.

      Parent
      Passionflower

      Anxiolytic herb shown comparable to oxazepam for generalized anxiety.

      Mechanism of action

      Flavonoid chrysin and apigenin modulate GABA-A benzodiazepine sites.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces pre-surgical anxiety

        Moderate evidence

        Comparable to oxazepam in GAD

        Limited evidence

        Potential side effects

        Common
        • · Sedation
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)
            Avoid / monitor with these medications
            • ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            250–500 mg extract
            With food?
            Either

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Passionflowe…
            Amazon
            Wide selection · fast shipping
            Herb
            Passionflowe…
            iHerb
            Global delivery · curated brands
            Herb
            Passionflowe…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (9)

            RCTAnesth Analg · 2008

            Passionflower in pre-op anxiety

            Movafegh A, et al.

            DB-RCT in 60 surgical patients.

            Key findings

            Reduced preoperative anxiety vs placebo without sedation.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Passionflower (Anxiety) — Reduces pre-surgical anxiety

            Live PubMed search

            Live results for "Passionflower (Anxiety) Reduces pre-surgical anxiety" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Passionflower (Anxiety) and "Reduces pre-surgical anxiety". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Passionflower (Anxiety) — Comparable to oxazepam in GAD

            Live PubMed search

            Live results for "Passionflower (Anxiety) Comparable to oxazepam in GAD" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Passionflower (Anxiety) and "Comparable to oxazepam in GAD". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Passionflower (Anxiety) — randomized controlled trial

            Live PubMed search

            Live results for "Passionflower (Anxiety) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Passionflower (Anxiety) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Passionflower (Anxiety) — meta-analysis

            Live PubMed search

            Live results for "Passionflower (Anxiety) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Passionflower (Anxiety) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Passionflower (Anxiety) — pharmacokinetics

            Live PubMed search

            Live results for "Passionflower (Anxiety) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Passionflower (Anxiety) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Passionflower (Anxiety) — safety adverse events

            Live PubMed search

            Live results for "Passionflower (Anxiety) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Passionflower (Anxiety) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Passionflower (Anxiety) — dose response

            Live PubMed search

            Live results for "Passionflower (Anxiety) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Passionflower (Anxiety) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Passionflower (Anxiety) — clinical evidence

            Live Scholar search

            Cross-database citation index for Passionflower (Anxiety) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.