Overview
Passiflora incarnata for mild GAD and pre-surgical anxiety.
- Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
- Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
- Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
- Standardized extract capsule
- Liquid tincture (alcohol or glycerin)
- Powdered whole herb
- Traditional decoction or tea
Forms & variants of Passionflower
Different chemical forms of Passionflower behave differently. Browse each form's mechanism, bioavailability, and best-use context.
Mechanism of action
Flavonoid chrysin and apigenin modulate GABA-A benzodiazepine sites.
- · Flavonoid chrysin
- · apigenin modulate GABA-A benzodiazepine sites
Effects on the body
Organ system effects
Passionflower (Anxiety) modulates monoaminergic and GABAergic tone relevant to mood and anxiety regulation.
Evidence-based benefits
Reduces pre-surgical anxiety
Moderate evidenceComparable to oxazepam in GAD
Limited evidencePotential side effects
- · Sedation
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
- ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)
Supplement interactions
- Magnesium glycinateComplementary GABAergic calming and improved sleep architecture.
- L-theanineReduces sleep latency without sedation.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Passionflower (Anxiety) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Passionflower (Anxiety) third party tested NSF
CapsulesPre-measured Passionflower (Anxiety) capsules — easiest for travel and consistent daily dosing without scoops or scales.Passionflower (Anxiety) capsules
PowderBulk unflavored Passionflower (Anxiety) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Passionflower (Anxiety) powder unflavored
Best sellersMost-purchased Passionflower (Anxiety) products on Amazon — a quick way to see what's reviewed widely before you commit.Passionflower (Anxiety) best sellerScientific evidence9Show studiesHide studies
Passionflower in pre-op anxiety
Movafegh A, et al.
DB-RCT in 60 surgical patients.
Reduced preoperative anxiety vs placebo without sedation.
PubMed: Passionflower (Anxiety) — Reduces pre-surgical anxiety
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PubMed: Passionflower (Anxiety) — Comparable to oxazepam in GAD
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PubMed: Passionflower (Anxiety) — randomized controlled trial
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PubMed: Passionflower (Anxiety) — meta-analysis
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PubMed: Passionflower (Anxiety) — pharmacokinetics
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PubMed: Passionflower (Anxiety) — dose response
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Google Scholar: Passionflower (Anxiety) — clinical evidence
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Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.