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evidence · mechanism · dose
Supplements/Herb

Hops Extract

aka Humulus lupulus

Bitter cone extract with mild sedative and phytoestrogenic effects.

Sleep & RecoveryMenopause Support

Overview

Bitter cone extract with mild sedative and phytoestrogenic effects.

Natural sources
    Common forms

      Mechanism of action

      Acts on melatonin and GABA receptors; 8-prenylnaringenin is a potent phytoestrogen.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves sleep when combined with valerian

        Moderate evidence

        Potential side effects

        Common
        • · Drowsiness
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)
            Avoid with these conditions
            • ·Hormone-sensitive cancers (breast, prostate, ovarian, uterine)
            Avoid / monitor with these medications
            • ·Hormonal contraceptives, HRT, tamoxifen, aromatase inhibitors
            • ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            300–400 mg extract
            With food?
            Evening

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Hops Extract
            Amazon
            Wide selection · fast shipping
            Herb
            Hops Extract
            iHerb
            Global delivery · curated brands
            Herb
            Hops Extract
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTPhytother Res · 2007

            Valerian-hops combination for insomnia

            Koetter U, et al.

            4-week DB-RCT in 91 mild insomnia patients.

            Key findings

            Valerian + hops improved sleep latency vs placebo and valerian alone.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Hops Extract — Improves sleep when combined with valerian

            Live PubMed search

            Live results for "Hops Extract Improves sleep when combined with valerian" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Hops Extract and "Improves sleep when combined with valerian". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Hops Extract — randomized controlled trial

            Live PubMed search

            Live results for "Hops Extract randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Hops Extract and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Hops Extract — meta-analysis

            Live PubMed search

            Live results for "Hops Extract meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Hops Extract and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Hops Extract — pharmacokinetics

            Live PubMed search

            Live results for "Hops Extract pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Hops Extract and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Hops Extract — safety adverse events

            Live PubMed search

            Live results for "Hops Extract safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Hops Extract and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Hops Extract — dose response

            Live PubMed search

            Live results for "Hops Extract dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Hops Extract and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Hops Extract — clinical evidence

            Live Scholar search

            Cross-database citation index for Hops Extract as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.