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California Poppy

Eschscholzia californica for anxiety and insomnia.

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Overview

Eschscholzia californica for anxiety and insomnia.

Natural sources
  • Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
  • Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
  • Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
Common forms
  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Mechanism of action

Alkaloids modulate GABA receptors and MAO.

Pathways
  • · Alkaloids modulate GABA receptors

Effects on the body

Supports
sleep quality

Organ system effects

Brain & CNS

California Poppy promotes parasympathetic tone, GABAergic signaling, or melatonergic pathways that facilitate sleep onset and quality.

Evidence-based benefits

Improves sleep quality

Moderate evidence

Potential side effects

Common
  • · Drowsiness
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose California Poppy use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Avoid / monitor with these medications
      • ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)

      Supplement interactions

      Pairs well with
      • Magnesium glycinate
        Complementary GABAergic calming and improved sleep architecture.
      • L-theanine
        Reduces sleep latency without sedation.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      500 mg before bed
      Best form
      Most evidence is based on the standardized extract capsule form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either with or without food.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTCurr Med Res Opin · 2004

      California poppy + valerian for anxiety

      Hanus M, et al.

      264 adults with anxiety

      Key findings

      Significant reduction in HAM-A scores vs placebo.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: California Poppy — Improves sleep quality

      Live PubMed search

      Live results for "California Poppy Improves sleep quality" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching California Poppy and "Improves sleep quality". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: California Poppy — randomized controlled trial

      Live PubMed search

      Live results for "California Poppy randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching California Poppy and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: California Poppy — meta-analysis

      Live PubMed search

      Live results for "California Poppy meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching California Poppy and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: California Poppy — pharmacokinetics

      Live PubMed search

      Live results for "California Poppy pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching California Poppy and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: California Poppy — safety adverse events

      Live PubMed search

      Live results for "California Poppy safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching California Poppy and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: California Poppy — dose response

      Live PubMed search

      Live results for "California Poppy dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching California Poppy and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: California Poppy — clinical evidence

      Live Scholar search

      Cross-database citation index for California Poppy as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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